SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q2 2018
Shares 356,608 Value ($000) $60,195 Avg Close — Range —
Q1 2018
Shares 650,308 Value ($000) $97,150 Avg Close — Range —
Q4 2017
Shares 272,508 Value ($000) $42,271 Avg Close — Range —
Q3 2017
Shares 399,908 Value ($000) $61,242 Avg Close — Range —
Q2 2017
Shares 548,808 Value ($000) $90,701 Avg Close — Range —
Q1 2017
Shares 897,451 Value ($000) $156,363 Avg Close — Range —
Q4 2016
Shares 1,203,351 Value ($000) $205,027 Avg Close — Range —
Q3 2016
Shares 1,063,351 Value ($000) $206,141 Avg Close — Range —
Q2 2016
Shares 394,009 Value ($000) $72,529 Avg Close — Range —
Q1 2016
Shares 300,371 Value ($000) $51,634 Avg Close — Range —
Q4 2015
Shares 250,971 Value ($000) $51,449 Avg Close — Range —
Q3 2015
Shares 664,400 Value ($000) $136,355 Avg Close — Range —
Q2 2015
Shares 1,306,000 Value ($000) $315,386 Avg Close — Range —
Q1 2015
Shares 1,385,000 Value ($000) $331,417 Avg Close — Range —
Q4 2014
Shares 1,170,000 Value ($000) $248,672 Avg Close — Range —
Q3 2014
Shares 1,219,000 Value ($000) $315,782 Avg Close — Range —
Q2 2014
Shares 905,200 Value ($000) $213,166 Avg Close — Range —
Q1 2014
Shares 587,000 Value ($000) $87,187 Avg Close — Range —
Q4 2013
Shares 724,000 Value ($000) $102,294 Avg Close — Range —
Q3 2013
Shares 690,900 Value ($000) $82,832 Avg Close — Range —