SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q2 2018
Shares 126,500 Value ($000) $21,353 Avg Close — Range —
Q1 2018
Shares 196,500 Value ($000) $29,355 Avg Close — Range —
Q4 2017
Shares 86,500 Value ($000) $13,418 Avg Close — Range —
Q3 2017
Shares 86,500 Value ($000) $13,247 Avg Close — Range —
Q2 2017
Shares 68,500 Value ($000) $11,321 Avg Close — Range —
Q1 2017
Shares 214,539 Value ($000) $15,424 Avg Close — Range —
Q4 2016
Shares 32,500 Value ($000) $5,537 Avg Close — Range —
Q3 2016
Shares 7,500 Value ($000) $1,454 Avg Close — Range —
Q2 2016
Shares 264,539 Value ($000) $21,599 Avg Close — Range —
Q1 2016
Shares 188,676 Value ($000) $16,479 Avg Close — Range —
Q4 2015
Shares 40,000 Value ($000) $8,200 Avg Close — Range —
Q3 2015
Shares 169,751 Value ($000) $13,252 Avg Close — Range —
Q2 2015
Shares 134,751 Value ($000) $6,866 Avg Close — Range —
Q1 2015
Shares 134,751 Value ($000) $7,229 Avg Close — Range —
Q4 2014
Shares 224,751 Value ($000) $15,886 Avg Close — Range —
Q3 2014
Shares 259,085 Value ($000) $22,429 Avg Close — Range —
Q2 2014
Shares 180,000 Value ($000) $14,065 Avg Close — Range —
Q4 2013
Shares 65,000 Value ($000) $9,184 Avg Close — Range —