| FMR LLC | 3,848,795 | $55,038 |
| SECTORAL ASSET MANAGEMENT INC | 492,435 | $7,042 |
| BlackRock, Inc. | 311,353 | $4,452 |
| TimesSquare Capital Management, LLC | 289,850 | $4,145 |
| Alyeska Investment Group, L.P. | 232,984 | $3,332 |
| Sio Capital Management, LLC | 227,971 | $3,260 |
| VANGUARD GROUP INC | 220,430 | $3,152 |
| Roubaix Capital, LLC | 158,816 | $2,271 |
| MORGAN STANLEY | 150,794 | $2,156 |
| GEODE CAPITAL MANAGEMENT, LLC | 110,303 | $1,578 |
| Walleye Capital LLC | 93,434 | $1,336 |
| MILLENNIUM MANAGEMENT LLC | 92,003 | $1,316 |
| FEDERATED HERMES, INC. | 87,726 | $1,254 |
| STATE STREET CORP | 58,422 | $835 |
| READYSTATE ASSET MANAGEMENT LP | 39,431 | $564 |
| NORTHERN TRUST CORP | 35,693 | $510 |
| CM Management, LLC | 25,000 | $358 |
| GSA CAPITAL PARTNERS LLP | 22,750 | $0 |
| CITADEL ADVISORS LLC | 18,780 | $269 |
| BANK OF AMERICA CORP /DE/ | 18,778 | $269 |
| JANE STREET GROUP, LLC | 16,367 | $234 |
| Board of Trustees of The Leland Stanford Junior University | 13,521 | $193 |
| RENAISSANCE TECHNOLOGIES LLC | 12,300 | $176 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11,779 | $168 |
| BARCLAYS PLC | 7,457 | $107 |
| CITIGROUP INC | 5,583 | $80 |
| WELLS FARGO & COMPANY/MN | 5,250 | $75 |
| DEUTSCHE BANK AG\ | 4,133 | $59 |
| RHUMBLINE ADVISERS | 3,131 | $45 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 2,301 | $33 |
| JPMORGAN CHASE & CO | 1,916 | $27 |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,800 | $26 |
| UBS Group AG | 1,566 | $22 |
| OSAIC HOLDINGS, INC. | 1,475 | $21 |
| BNP PARIBAS ARBITRAGE, SA | 1,048 | $15 |
| Steward Partners Investment Advisory, LLC | 1,000 | $14 |
| ROYAL BANK OF CANADA | 754 | $11 |
| Tower Research Capital LLC (TRC) | 702 | $10 |
| Legal & General Group Plc | 462 | $7 |
| Russell Investments Group, Ltd. | 408 | $6 |
| Ameritas Investment Partners, Inc. | 400 | $6 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 293 | $4 |
| CWM, LLC | 151 | $0 |
| AMALGAMATED BANK | 150 | $0 |
| Sterling Capital Management LLC | 126 | $2 |
| NATIONAL BANK OF CANADA /FI/ | 27 | $0 |
| EverSource Wealth Advisors, LLC | 7 | $0 |
| IFP Advisors, Inc | 1 | $0 |
| True Wealth Design, LLC | 1 | $0 |