SILENCE THERAPEUTICS PLC

Ticker: SLN CUSIP: 82686Q101 Class: ADR

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 39,344 Value ($000) $239 Avg Close — Range —
Q3 2025
Shares 63,247 Value ($000) $328 Avg Close — Range —
Q2 2025
Shares 59,312 Value ($000) $344 Avg Close — Range —
Q1 2025
Shares 76,008 Value ($000) $214 Avg Close — Range —
Q4 2024
Shares 142,052 Value ($000) $977 Avg Close — Range —
Q3 2024
Shares 169,392 Value ($000) $3,080 Avg Close — Range —
Q2 2024
Shares 99,107 Value ($000) $1,883 Avg Close — Range —
Q1 2024
Shares 107,212 Value ($000) $2,316 Avg Close — Range —