| TCG Crossover Management, LLC | 3,033,560 | $18,444 |
| Siren, L.L.C. | 2,911,438 | $17,702 |
| Redmile Group, LLC | 2,164,777 | $13,162 |
| Nantahala Capital Management, LLC | 1,542,427 | $9,378 |
| Vivo Capital, LLC | 1,105,454 | $6,721 |
| Nextech Invest, Ltd. | 952,400 | $5,791 |
| Ikarian Capital, LLC | 865,784 | $1,732 |
| GREAT POINT PARTNERS LLC | 808,032 | $4,913 |
| MILLENNIUM MANAGEMENT LLC | 659,592 | $4,010 |
| 5AM Venture Management, LLC | 476,200 | $2,895 |
| Tetragon Partners GP Ltd | 365,369 | $2,221 |
| MORGAN STANLEY | 324,630 | $1,974 |
| SG Americas Securities, LLC | 256,340 | $2 |
| Lombard Odier Asset Management (USA) Corp | 255,901 | $1,154 |
| CITADEL ADVISORS LLC | 244,061 | $1,484 |
| Ishara Investments LP | 240,000 | $1,459 |
| BOOTHBAY FUND MANAGEMENT, LLC | 209,088 | $1,271 |
| UBS Group AG | 207,513 | $1,262 |
| M28 Capital Management LP | 185,100 | $1,125 |
| HSBC HOLDINGS PLC | 172,834 | $1,072 |
| BANK OF MONTREAL /CAN/ | 160,474 | $976 |
| MARSHALL WACE, LLP | 155,680 | $947 |
| Seven Fleet Capital Management LP | 147,600 | $897 |
| Point72 Asset Management, L.P. | 114,070 | $694 |
| Opaleye Management Inc. | 78,926 | $480 |
| BlackRock, Inc. | 73,153 | $445 |
| Quadrature Capital Ltd | 54,380 | $331 |
| TWO SIGMA INVESTMENTS, LP | 39,344 | $239 |
| Qube Research & Technologies Ltd | 34,962 | $213 |
| GEODE CAPITAL MANAGEMENT, LLC | 29,538 | $180 |
| JANE STREET GROUP, LLC | 29,168 | $177 |
| RAYMOND JAMES FINANCIAL INC | 25,000 | $152 |
| ADAR1 Capital Management, LLC | 23,643 | $144 |
| GOLDMAN SACHS GROUP INC | 18,114 | $110 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,866 | $103 |
| TWO SIGMA ADVISERS, LP | 15,900 | $97 |
| China Universal Asset Management Co., Ltd. | 13,653 | $83 |
| RHUMBLINE ADVISERS | 12,999 | $79 |
| BNP PARIBAS ARBITRAGE, SA | 12,027 | $73 |
| XTX Topco Ltd | 11,718 | $71 |
| GAMMA Investing LLC | 10,112 | $61 |
| JPMORGAN CHASE & CO | 7,942 | $48 |
| BARCLAYS PLC | 5,065 | $31 |
| SIMPLEX TRADING, LLC | 3,991 | $24 |
| BANK OF AMERICA CORP /DE/ | 2,966 | $18 |
| JONES FINANCIAL COMPANIES LLLP | 2,500 | $15 |
| Tower Research Capital LLC (TRC) | 2,448 | $15 |
| Mirae Asset Global Investments Co., Ltd. | 2,282 | $14 |
| CITIGROUP INC | 1,621 | $10 |
| Parallel Advisors, LLC | 1,300 | $8 |
| Global Retirement Partners, LLC | 1,000 | $6 |
| GF FUND MANAGEMENT CO. LTD. | 922 | $6 |
| Steward Partners Investment Advisory, LLC | 100 | $1 |
| Rockefeller Capital Management L.P. | 45 | $0 |
| SBI Securities Co., Ltd. | 28 | $0 |
| ROYAL BANK OF CANADA | 16 | $0 |
| SageView Advisory Group, LLC | 11 | $0 |
| OSAIC HOLDINGS, INC. | 3 | $0 |