SIONNA THERAPEUTICS INC

Ticker: SION CUSIP: 829401108 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 6,400 Value ($000) $263 Avg Close $37.92 Range $24.65 - $45.00

Q1 2025

Shares 11,715 Value ($000) $123 Avg Close $16.34 Range $10.27 - $25.19

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	6,400	$263	$37.92	$24.65 - $45.00
Q1 2025	11,715	$123	$16.34	$10.27 - $25.19