| RA CAPITAL MANAGEMENT, L.P. | 9,905,045 | $407,494 |
| TPG GP A, LLC | 6,744,962 | $277,488 |
| ORBIMED ADVISORS LLC | 3,561,655 | $146,526 |
| VIKING GLOBAL INVESTORS LP | 3,195,181 | $131,450 |
| Atlas Venture Life Science Advisors, LLC | 2,995,602 | $123,239 |
| Enavate Sciences GP, LLC | 2,478,030 | $101,946 |
| BlackRock, Inc. | 1,291,599 | $53,136 |
| JPMORGAN CHASE & CO | 1,231,819 | $50,677 |
| VANGUARD GROUP INC | 1,184,951 | $48,749 |
| PERCEPTIVE ADVISORS LLC | 1,179,098 | $48,508 |
| JENNISON ASSOCIATES LLC | 1,115,278 | $45,883 |
| CITADEL ADVISORS LLC | 1,087,325 | $44,733 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 970,590 | $39,930 |
| abrdn plc | 839,960 | $34,556 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 831,373 | $34 |
| STATE STREET CORP | 693,395 | $28,526 |
| EVENTIDE ASSET MANAGEMENT, LLC | 639,045 | $26,290 |
| BAKER BROS. ADVISORS LP | 400,000 | $16,456 |
| GEODE CAPITAL MANAGEMENT, LLC | 380,042 | $15,638 |
| Siren, L.L.C. | 300,000 | $12,342 |
| Soleus Capital Management, L.P. | 268,500 | $11,046 |
| Kalehua Capital Management LLC | 197,072 | $8,108 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 180,593 | $7,430 |
| FRANKLIN RESOURCES INC | 175,483 | $7,219 |
| Alyeska Investment Group, L.P. | 136,222 | $5,604 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 123,686 | $5,088 |
| Artia Global Partners LP | 119,741 | $4,926 |
| TD Asset Management Inc | 113,352 | $4,663 |
| NORTHERN TRUST CORP | 112,116 | $4,612 |
| Invesco Ltd. | 111,162 | $4,573 |
| AMERIPRISE FINANCIAL INC | 101,643 | $4,182 |
| Rock Springs Capital Management LP | 99,429 | $4,091 |
| UBS Group AG | 89,177 | $3,669 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 83,850 | $3,450 |
| MILLENNIUM MANAGEMENT LLC | 80,546 | $3,314 |
| Ensign Peak Advisors, Inc | 79,862 | $3,286 |
| Longaeva Partners L.P. | 79,729 | $3,280 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69,424 | $2,872 |
| SEVEN GRAND MANAGERS, LLC | 50,000 | $2,057 |
| MORGAN STANLEY | 49,876 | $2,052 |
| BARCLAYS PLC | 48,172 | $1,982 |
| BANK OF AMERICA CORP /DE/ | 43,567 | $1,792 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 41,460 | $1,706 |
| WELLINGTON MANAGEMENT GROUP LLP | 38,347 | $1,578 |
| ALPS ADVISORS INC | 36,648 | $1,508 |
| GOLDMAN SACHS GROUP INC | 36,269 | $1,492 |
| Bank of New York Mellon Corp | 35,134 | $1,445 |
| POLEN CAPITAL MANAGEMENT LLC | 31,258 | $1,286 |
| Rafferty Asset Management, LLC | 24,690 | $1,016 |
| Nuveen, LLC | 23,734 | $976 |
| Russell Investments Group, Ltd. | 21,941 | $903 |
| RHUMBLINE ADVISERS | 17,694 | $728 |
| WELLS FARGO & COMPANY/MN | 17,551 | $722 |
| Squarepoint Ops LLC | 16,360 | $673 |
| ALLIANCEBERNSTEIN L.P. | 15,620 | $643 |
| SG Americas Securities, LLC | 10,691 | $0 |
| China Universal Asset Management Co., Ltd. | 10,272 | $423 |
| DEUTSCHE BANK AG\ | 10,029 | $413 |
| PROFUND ADVISORS LLC | 9,213 | $379 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,915 | $367 |
| MetLife Investment Management, LLC | 8,565 | $352 |
| INTECH INVESTMENT MANAGEMENT LLC | 7,589 | $312 |
| KENNEDY CAPITAL MANAGEMENT LLC | 6,752 | $278 |
| TWO SIGMA INVESTMENTS, LP | 6,400 | $263 |
| Virtus Investment Advisers, LLC | 6,220 | $256 |
| AMERICAN CENTURY COMPANIES INC | 6,180 | $254 |
| DARK FOREST CAPITAL MANAGEMENT LP | 5,991 | $246 |
| D. E. Shaw & Co., Inc. | 5,742 | $236 |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,300 | $218 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 5,189 | $197 |
| CITIGROUP INC | 5,185 | $213 |
| XTX Topco Ltd | 4,926 | $203 |
| ProShare Advisors LLC | 4,903 | $202 |
| CIBC Private Wealth Group, LLC | 4,500 | $185 |
| Police & Firemen's Retirement System of New Jersey | 4,232 | $174 |
| AlphaCentric Advisors LLC | 2,720 | $112 |
| BNP PARIBAS ARBITRAGE, SA | 2,264 | $93 |
| Mirae Asset Global Investments Co., Ltd. | 2,169 | $89 |
| Legal & General Group Plc | 1,682 | $69 |
| BALYASNY ASSET MANAGEMENT L.P. | 1,406 | $58 |
| Ameritas Investment Partners, Inc. | 1,302 | $54 |
| Tower Research Capital LLC (TRC) | 1,129 | $46 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 988 | $41 |
| GF FUND MANAGEMENT CO. LTD. | 876 | $36 |
| AMALGAMATED BANK | 504 | $0 |
| ROYAL BANK OF CANADA | 489 | $21 |
| FMR LLC | 384 | $16 |
| Farther Finance Advisors, LLC | 190 | $8 |
| GAMMA Investing LLC | 177 | $7 |
| Daiwa Securities Group Inc. | 149 | $0 |
| Sterling Capital Management LLC | 105 | $4 |
| CWM, LLC | 80 | $0 |
| US BANCORP \DE\ | 65 | $3 |
| Rockefeller Capital Management L.P. | 48 | $2 |
| Aster Capital Management (DIFC) Ltd | 37 | $2 |
| Allworth Financial LP | 28 | $1 |
| Hughes Financial Services, LLC | 25 | $1 |
| EverSource Wealth Advisors, LLC | 20 | $1 |
| PNC Financial Services Group, Inc. | 5 | $0 |
| ROTHSCHILD INVESTMENT LLC | 1 | $0 |