SIONNA THERAPEUTICS INC

Ticker: SION CUSIP: 829401108 Class: Common Stock

RA CAPITAL MANAGEMENT, L.P.'s Holding History (CIK: 0001346824)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 9,905,045 Value ($000) $407,494 Avg Close $37.92 Range $24.65 - $45.00

Q3 2025

Shares 10,445,322 Value ($000) $307,197 Avg Close $21.76 Range $16.14 - $30.61

Q2 2025

Shares 10,445,322 Value ($000) $181,226 Avg Close $13.10 Range $7.25 - $18.85

Q1 2025

Shares 10,445,322 Value ($000) $109,258 Avg Close $16.34 Range $10.27 - $25.19

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	9,905,045	$407,494	$37.92	$24.65 - $45.00
Q3 2025	10,445,322	$307,197	$21.76	$16.14 - $30.61
Q2 2025	10,445,322	$181,226	$13.10	$7.25 - $18.85
Q1 2025	10,445,322	$109,258	$16.34	$10.27 - $25.19