SKYE BIOSCIENCE INC

Ticker: SKYE CUSIP: 83086J200 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 51,706 Value ($000) $39 Avg Close $1.46 Range $0.68 - $4.99

Q3 2025

Shares 92,318 Value ($000) $363 Avg Close $3.78 Range $2.96 - $4.75

Q2 2025

Shares 63,155 Value ($000) $264 Avg Close $2.07 Range $1.14 - $5.75

Q1 2025

Shares 16,607 Value ($000) $26 Avg Close $2.73 Range $1.56 - $4.25

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	51,706	$39	$1.46	$0.68 - $4.99
Q3 2025	92,318	$363	$3.78	$2.96 - $4.75
Q2 2025	63,155	$264	$2.07	$1.14 - $5.75
Q1 2025	16,607	$26	$2.73	$1.56 - $4.25