SKYE BIOSCIENCE INC

Ticker: SKYE CUSIP: 83086J200 Class: Common Stock

Holders for Q4 2025 Position Changes for Q4 2025

Note: Option positions (PUT/CALL) are excluded.

InstitutionSharesValue ($000)
5AM Venture Management, LLC9,681,763$7,258
Versant Venture Management, LLC2,007,704$1,505
BAKER BROS. ADVISORS LP1,450,638$1,088
VANGUARD GROUP INC882,785$662
SPHERA FUNDS MANAGEMENT LTD.478,928$359
MILLENNIUM MANAGEMENT LLC380,478$285
BlackRock, Inc.281,841$211
PLATINUM INVESTMENT MANAGEMENT LTD233,095$175
GEODE CAPITAL MANAGEMENT, LLC210,151$158
Schonfeld Strategic Advisors LLC93,407$70
STATE STREET CORP75,326$56
XTX Topco Ltd53,040$40
TWO SIGMA INVESTMENTS, LP51,706$39
TWO SIGMA ADVISERS, LP40,982$31
HRT FINANCIAL LP27,348$0
JANE STREET GROUP, LLC24,615$18
Engineers Gate Manager LP23,138$17
GSA CAPITAL PARTNERS LLP22,877$0
BARCLAYS PLC21,251$16
NORTHERN TRUST CORP20,142$15
GROUP ONE TRADING, L.P.17,697$13
R Squared Ltd14,782$11
UBS Group AG13,286$10
CAPITAL ADVISORS INC/OK10,000$7
SIMPLEX TRADING, LLC6,331$5
MORGAN STANLEY4,269$3
FEDERATED HERMES, INC.1,158$1
FMR LLC748$1
BANK OF AMERICA CORP /DE/586$0
BNP PARIBAS ARBITRAGE, SA510$0
NATIONAL BANK OF CANADA /FI/400$0
Fortitude Family Office, LLC385$0
ROYAL BANK OF CANADA124$0
JPMORGAN CHASE & CO66$0
Zurcher Kantonalbank (Zurich Cantonalbank)52$0
Federation des caisses Desjardins du Quebec51$0
Rockefeller Capital Management L.P.39$0
TD Waterhouse Canada Inc.25$0
Optiver Holding B.V.20$0
Newbridge Financial Services Group, Inc.18$0
Dynamic Wealth Strategies, LLC8$0
CoreCap Advisors, LLC8$0
Plante Moran Financial Advisors, LLC3$0
OSAIC HOLDINGS, INC.2$0
MCGUIRE CAPITAL ADVISORS INC2$0
WELLS FARGO & COMPANY/MN1$0
HARBOUR INVESTMENTS, INC.1$0
IFP Advisors, Inc1$0
TUCKER ASSET MANAGEMENT LLC1$0
PFS Partners, LLC1$0
Total (50 institutions)16,131,790$12,057