SKYE BIOSCIENCE INC

Ticker: SKYE CUSIP: 83086J200 Class: Common Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 40,982 Value ($000) $31 Avg Close $1.46 Range $0.68 - $4.99

Q4 2024

Shares 11,200 Value ($000) $32 Avg Close $4.18 Range $2.31 - $5.96

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	40,982	$31	$1.46	$0.68 - $4.99
Q4 2024	11,200	$32	$4.18	$2.31 - $5.96