SOLENO THERAPEUTICS INC

Ticker: SLNO CUSIP: 834203309 Class: Common Stock

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 5,767 Value ($000) $267 Avg Close $54.83 Range $41.80 - $72.88

Q3 2025

Shares 7,766 Value ($000) $525 Avg Close $74.14 Range $48.91 - $90.32

Q2 2025

Shares 114,690 Value ($000) $9,609 Avg Close $74.85 Range $57.01 - $86.79

Q1 2025

Shares 16,672 Value ($000) $1,191 Avg Close $48.69 Range $41.50 - $73.97

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	5,767	$267	$54.83	$41.80 - $72.88
Q3 2025	7,766	$525	$74.14	$48.91 - $90.32
Q2 2025	114,690	$9,609	$74.85	$57.01 - $86.79
Q1 2025	16,672	$1,191	$48.69	$41.50 - $73.97