| FMR LLC | 8,079,304 | $374,072 |
| JANUS HENDERSON GROUP PLC | 7,178,354 | $332,302 |
| BlackRock, Inc. | 3,871,639 | $179,257 |
| WELLINGTON MANAGEMENT GROUP LLP | 3,322,799 | $153,846 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,318,698 | $154 |
| VANGUARD GROUP INC | 3,060,361 | $141,695 |
| Avoro Capital Advisors LLC | 2,900,000 | $134,270 |
| STATE STREET CORP | 2,649,626 | $122,678 |
| Nantahala Capital Management, LLC | 1,314,002 | $60,838 |
| MILLENNIUM MANAGEMENT LLC | 1,236,321 | $57,242 |
| Commodore Capital LP | 1,200,000 | $55,560 |
| BRAIDWELL LP | 1,187,859 | $54,998 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,163,338 | $53,871 |
| Polar Capital Holdings Plc | 1,136,929 | $52,640 |
| Woodline Partners LP | 1,111,778 | $51,475 |
| Deep Track Capital, LP | 1,000,000 | $46,300 |
| GOLDMAN SACHS GROUP INC | 913,050 | $42,274 |
| Vivo Capital, LLC | 894,909 | $41,434 |
| Invesco Ltd. | 875,019 | $40,513 |
| READYSTATE ASSET MANAGEMENT LP | 874,447 | $40,487 |
| FRANKLIN RESOURCES INC | 823,958 | $38,149 |
| Pictet Asset Management Holding SA | 624,128 | $28,897 |
| Bank of New York Mellon Corp | 621,811 | $28,790 |
| Hood River Capital Management LLC | 618,005 | $28,614 |
| Artia Global Partners LP | 533,698 | $24,710 |
| Squarepoint Ops LLC | 468,654 | $21,699 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 449,848 | $20,823 |
| EMERALD ADVISERS, LLC | 412,651 | $19,106 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 401,186 | $18,575 |
| GREAT POINT PARTNERS LLC | 400,000 | $18,520 |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 399,900 | $18,515 |
| Assenagon Asset Management S.A. | 384,166 | $17,787 |
| NORTHERN TRUST CORP | 365,418 | $16,919 |
| Catalio Capital Management, LP | 360,340 | $16,684 |
| Integral Health Asset Management, LLC | 325,000 | $15,048 |
| CITADEL ADVISORS LLC | 308,830 | $14,299 |
| Logos Global Management LP | 300,000 | $13,890 |
| MORGAN STANLEY | 287,639 | $13,318 |
| abrdn plc | 287,456 | $13,309 |
| Qube Research & Technologies Ltd | 287,293 | $13,302 |
| Penn Capital Management Company, LLC | 275,782 | $12,797 |
| PFM Health Sciences, LP | 247,893 | $11,477 |
| Rock Springs Capital Management LP | 247,053 | $11,439 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 244,358 | $11,314 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 232,485 | $10,764 |
| BALYASNY ASSET MANAGEMENT L.P. | 227,751 | $10,545 |
| Alyeska Investment Group, L.P. | 217,500 | $10,070 |
| BNP PARIBAS ARBITRAGE, SA | 212,818 | $9,853 |
| SummitTX Capital, L.P. | 211,727 | $9,803 |
| BANK OF AMERICA CORP /DE/ | 208,595 | $9,658 |
| Skandinaviska Enskilda Banken AB (publ) | 187,475 | $8,680 |
| NEW YORK STATE COMMON RETIREMENT FUND | 185,317 | $8,580 |
| Clark Capital Management Group, Inc. | 180,250 | $8,346 |
| UBS Group AG | 169,506 | $7,848 |
| Ally Bridge Group (NY) LLC | 168,029 | $7,780 |
| Engineers Gate Manager LP | 168,005 | $7,779 |
| BARCLAYS PLC | 157,685 | $7,301 |
| Buckley Capital Advisors, LLC | 149,150 | $6,906 |
| Brevan Howard Capital Management LP | 147,800 | $6,843 |
| Capital World Investors | 145,522 | $6,738 |
| DEUTSCHE BANK AG\ | 141,982 | $6,574 |
| JANE STREET GROUP, LLC | 141,740 | $6,563 |
| Granahan Investment Management, LLC | 137,592 | $6,371 |
| SPHERA FUNDS MANAGEMENT LTD. | 136,314 | $6,311 |
| Eagle Health Investments LP | 135,100 | $6,255 |
| HighVista Strategies LLC | 135,069 | $6,254 |
| Trexquant Investment LP | 132,912 | $6,154 |
| Seven Fleet Capital Management LP | 130,079 | $6,023 |
| ROYCE & ASSOCIATES LP | 129,043 | $5,975 |
| NAN FUNG TRINITY (HK) LTD | 123,850 | $5,734 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 119,695 | $5,542 |
| PEREGRINE CAPITAL MANAGEMENT LLC | 119,564 | $5,536 |
| Centiva Capital, LP | 118,804 | $5,501 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 117,485 | $5,440 |
| JPMORGAN CHASE & CO | 115,517 | $5,348 |
| Nuveen, LLC | 100,622 | $4,659 |
| Rafferty Asset Management, LLC | 95,597 | $4,426 |
| Swiss National Bank | 89,100 | $4,125 |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 83,166 | $3,851 |
| STATE OF WISCONSIN INVESTMENT BOARD | 72,482 | $3,356 |
| UBS ASSET MANAGEMENT AMERICAS INC | 72,360 | $3,350 |
| Ikarian Capital, LLC | 68,823 | $3,187 |
| SEI INVESTMENTS CO | 67,330 | $3,118 |
| HealthInvest Partners AB | 62,735 | $2,905 |
| KVP Capital Advisors, LP | 59,700 | $2,764 |
| AQR CAPITAL MANAGEMENT LLC | 58,752 | $2,720 |
| RHUMBLINE ADVISERS | 55,068 | $2,550 |
| Jump Financial, LLC | 54,487 | $2,523 |
| DV Trading LLC | 54,000 | $2,500 |
| WELLS FARGO & COMPANY/MN | 52,643 | $2,437 |
| SIMPLEX TRADING, LLC | 49,108 | $2,274 |
| LAZARD ASSET MANAGEMENT LLC | 48,445 | $2,243 |
| Russell Investments Group, Ltd. | 46,678 | $2,161 |
| Moody Aldrich Partners LLC | 46,306 | $2,144 |
| WINTON GROUP Ltd | 44,200 | $2,046 |
| BOOTHBAY FUND MANAGEMENT, LLC | 43,862 | $2,031 |
| BANQUE PICTET & CIE SA | 43,796 | $2,028 |
| ALLIANCEBERNSTEIN L.P. | 42,290 | $1,958 |
| Caption Management, LLC | 42,100 | $1,949 |
| ADAR1 Capital Management, LLC | 41,830 | $1,937 |
| 145 other institutions | 1,483,283 | $60,440 |