SPERO THERAPEUTICS INC

Ticker: SPRO CUSIP: 84833T103 Class: COM

DIMENSIONAL FUND ADVISORS LP's Holding History (CIK: 0000354204)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 29,768 Value ($000) $69 Avg Close $2.32 Range $1.89 - $2.75

Q3 2025

Shares 28,994 Value ($000) $55 Avg Close $2.20 Range $1.80 - $3.22

Q4 2024

Shares 10,003 Value ($000) $10 Avg Close $1.19 Range $0.92 - $1.36

Q3 2024

Shares 10,003 Value ($000) $13 Avg Close $1.34 Range $1.15 - $1.53

Q2 2024

Shares 10,003 Value ($000) $13 Avg Close $1.51 Range $1.25 - $1.81

Q1 2024

Shares 10,003 Value ($000) $17 Avg Close $1.57 Range $1.33 - $1.89

Q4 2023

Shares 10,003 Value ($000) $15 Avg Close $1.19 Range $0.99 - $1.50

Q3 2023

Shares 11,753 Value ($000) $14 Avg Close $1.39 Range $1.18 - $1.66

Q2 2023

Shares 11,753 Value ($000) $17 Avg Close $1.71 Range $1.39 - $2.00

Q1 2023

Shares 11,753 Value ($000) $17 Avg Close $1.67 Range $1.35 - $2.04

Q4 2022

Shares 11,753 Value ($000) $0 Avg Close $1.87 Range $1.46 - $2.28

Q3 2022

Shares 10,003 Value ($000) $20 Avg Close $0.99 Range $0.68 - $3.18

Q2 2022

Shares 284,956 Value ($000) $212 Avg Close $2.91 Range $0.73 - $7.87

Q1 2022

Shares 406,946 Value ($000) $3,540 Avg Close $10.25 Range $7.51 - $16.30

Q4 2021

Shares 371,222 Value ($000) $5,943 Avg Close $15.88 Range $12.64 - $18.84

Q3 2021

Shares 329,633 Value ($000) $6,068 Avg Close $16.05 Range $12.75 - $19.87

Q2 2021

Shares 374,443 Value ($000) $5,227 Avg Close $13.97 Range $11.75 - $15.94

Q1 2021

Shares 342,506 Value ($000) $5,041 Avg Close $17.60 Range $12.70 - $22.23

Q4 2020

Shares 250,197 Value ($000) $4,852 Avg Close $15.59 Range $11.03 - $23.64

Q3 2020

Shares 231,009 Value ($000) $2,577 Avg Close $11.83 Range $8.50 - $14.37

Q2 2020

Shares 214,155 Value ($000) $2,897 Avg Close $11.23 Range $6.88 - $14.48

Q1 2020

Shares 198,861 Value ($000) $1,607 Avg Close $8.81 Range $5.25 - $10.84

Q4 2019

Shares 155,480 Value ($000) $1,495 Avg Close $10.78 Range $8.74 - $12.46

Q3 2019

Shares 123,005 Value ($000) $1,304 Avg Close $10.54 Range $8.86 - $12.65

Q2 2019

Shares 106,403 Value ($000) $1,224 Avg Close $12.04 Range $9.91 - $14.48

Q1 2019

Shares 17,869 Value ($000) $229 Avg Close $10.61 Range $6.00 - $13.50

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	29,768	$69	$2.32	$1.89 - $2.75
Q3 2025	28,994	$55	$2.20	$1.80 - $3.22
Q4 2024	10,003	$10	$1.19	$0.92 - $1.36
Q3 2024	10,003	$13	$1.34	$1.15 - $1.53
Q2 2024	10,003	$13	$1.51	$1.25 - $1.81
Q1 2024	10,003	$17	$1.57	$1.33 - $1.89
Q4 2023	10,003	$15	$1.19	$0.99 - $1.50
Q3 2023	11,753	$14	$1.39	$1.18 - $1.66
Q2 2023	11,753	$17	$1.71	$1.39 - $2.00
Q1 2023	11,753	$17	$1.67	$1.35 - $2.04
Q4 2022	11,753	$0	$1.87	$1.46 - $2.28
Q3 2022	10,003	$20	$0.99	$0.68 - $3.18
Q2 2022	284,956	$212	$2.91	$0.73 - $7.87
Q1 2022	406,946	$3,540	$10.25	$7.51 - $16.30
Q4 2021	371,222	$5,943	$15.88	$12.64 - $18.84
Q3 2021	329,633	$6,068	$16.05	$12.75 - $19.87
Q2 2021	374,443	$5,227	$13.97	$11.75 - $15.94
Q1 2021	342,506	$5,041	$17.60	$12.70 - $22.23
Q4 2020	250,197	$4,852	$15.59	$11.03 - $23.64
Q3 2020	231,009	$2,577	$11.83	$8.50 - $14.37
Q2 2020	214,155	$2,897	$11.23	$6.88 - $14.48
Q1 2020	198,861	$1,607	$8.81	$5.25 - $10.84
Q4 2019	155,480	$1,495	$10.78	$8.74 - $12.46
Q3 2019	123,005	$1,304	$10.54	$8.86 - $12.65
Q2 2019	106,403	$1,224	$12.04	$9.91 - $14.48
Q1 2019	17,869	$229	$10.61	$6.00 - $13.50