SPERO THERAPEUTICS INC

Ticker: SPRO CUSIP: 84833T103 Class: COM

Note: Option positions (PUT/CALL) are excluded.

InstitutionSharesValue ($000)
GSK plc9,190,606$21,414
Pfizer Inc2,362,348$5,504
VANGUARD GROUP INC2,083,462$4,854
RENAISSANCE TECHNOLOGIES LLC1,279,522$2,981
Alphabet Inc.889,979$2,074
Anson Funds Management LP625,062$1,456
GEODE CAPITAL MANAGEMENT, LLC529,195$1,233
BlackRock, Inc.433,616$1,010
CITADEL ADVISORS LLC397,864$927
TWO SIGMA INVESTMENTS, LP372,570$868
SUSQUEHANNA INTERNATIONAL GROUP, LLP293,700$684
EAM Investors, LLC218,084$508
TWO SIGMA ADVISERS, LP216,600$505
STATE STREET CORP210,151$490
Ionic Capital Management LLC195,939$457
GSA CAPITAL PARTNERS LLP178,930$0
INTREPID FAMILY OFFICE LLC165,000$384
JANE STREET GROUP, LLC158,344$369
SEI INVESTMENTS CO132,010$308
OMERS ADMINISTRATION Corp131,127$306
NORTHERN TRUST CORP120,984$282
Squarepoint Ops LLC119,434$278
UBS Group AG116,447$271
BRIDGEWAY CAPITAL MANAGEMENT, LLC114,800$267
ADAR1 Capital Management, LLC113,839$265
Shay Capital LLC60,289$140
Point72 Asset Management, L.P.43,579$102
Quadrature Capital Ltd37,799$88
SIMPLEX TRADING, LLC35,686$83
Capital Asset Advisory Services LLC32,548$82
AXXCESS WEALTH MANAGEMENT, LLC32,548$76
Three Seasons Wealth, LLC30,000$70
DIMENSIONAL FUND ADVISORS LP29,768$69
CHARLES SCHWAB INVESTMENT MANAGEMENT INC28,565$67
Invesco Ltd.24,705$58
MILLENNIUM MANAGEMENT LLC24,107$56
Assenagon Asset Management S.A.18,636$43
Torrey Growth & Income Advisors17,025$40
XTX Topco Ltd15,175$35
Texas Yale Capital Corp.10,000$23
Tower Research Capital LLC (TRC)7,215$17
JONES FINANCIAL COMPANIES LLLP6,477$15
JPMORGAN CHASE & CO5,373$13
FNY Investment Advisers, LLC5,300$0
CULLEN/FROST BANKERS, INC.3,000$7
BANK OF AMERICA CORP /DE/744$2
MORGAN STANLEY313$1
OSAIC HOLDINGS, INC.290$1
WELLS FARGO & COMPANY/MN200$0
Rockefeller Capital Management L.P.200$0
US BANCORP \DE\151$0
BNP PARIBAS ARBITRAGE, SA40$0
CITIGROUP INC17$0
SageView Advisory Group, LLC17$0
Farther Finance Advisors, LLC10$0
SBI Securities Co., Ltd.9$0
Total (56 institutions)21,119,399$48,785