SPERO THERAPEUTICS INC

Ticker: SPRO CUSIP: 84833T103 Class: COM

Assenagon Asset Management S.A.'s Holding History (CIK: 0001546007)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 18,636 Value ($000) $43 Avg Close $2.32 Range $1.89 - $2.75

Q3 2025

Shares 36,993 Value ($000) $70 Avg Close $2.20 Range $1.80 - $3.22

Q2 2022

Shares 131,020 Value ($000) $97 Avg Close $2.91 Range $0.73 - $7.87

Q1 2022

Shares 23,123 Value ($000) $201 Avg Close $10.25 Range $7.51 - $16.30

Q1 2021

Shares 181,578 Value ($000) $2,673 Avg Close $17.60 Range $12.70 - $22.23

Q4 2020

Shares 123,785 Value ($000) $2,400 Avg Close $15.59 Range $11.03 - $23.64

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	18,636	$43	$2.32	$1.89 - $2.75
Q3 2025	36,993	$70	$2.20	$1.80 - $3.22
Q2 2022	131,020	$97	$2.91	$0.73 - $7.87
Q1 2022	23,123	$201	$10.25	$7.51 - $16.30
Q1 2021	181,578	$2,673	$17.60	$12.70 - $22.23
Q4 2020	123,785	$2,400	$15.59	$11.03 - $23.64