SPERO THERAPEUTICS INC

Ticker: SPRO CUSIP: 84833T103 Class: COM

JANE STREET GROUP, LLC's Holding History (CIK: 0001595888)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 158,344 Value ($000) $369 Avg Close $2.32 Range $1.89 - $2.75

Q3 2025

Shares 42,988 Value ($000) $81 Avg Close $2.20 Range $1.80 - $3.22

Q4 2024

Shares 52,869 Value ($000) $54 Avg Close $1.19 Range $0.92 - $1.36

Q3 2022

Shares 15,496 Value ($000) $31 Avg Close $0.99 Range $0.68 - $3.18

Q1 2022

Shares 15,622 Value ($000) $136 Avg Close $10.25 Range $7.51 - $16.30

Q1 2021

Shares 11,496 Value ($000) $169 Avg Close $17.60 Range $12.70 - $22.23

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	158,344	$369	$2.32	$1.89 - $2.75
Q3 2025	42,988	$81	$2.20	$1.80 - $3.22
Q4 2024	52,869	$54	$1.19	$0.92 - $1.36
Q3 2022	15,496	$31	$0.99	$0.68 - $3.18
Q1 2022	15,622	$136	$10.25	$7.51 - $16.30
Q1 2021	11,496	$169	$17.60	$12.70 - $22.23