| FMR LLC | 8,712,251 | $605,937 |
| WELLINGTON MANAGEMENT GROUP LLP | 7,121,984 | $495,334 |
| Avoro Capital Advisors LLC | 6,555,555 | $455,939 |
| JANUS HENDERSON GROUP PLC | 5,090,148 | $354,006 |
| Deep Track Capital, LP | 4,111,782 | $285,974 |
| BVF INC/IL | 3,479,022 | $241,966 |
| MORGAN STANLEY | 2,087,834 | $145,209 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,671,138 | $116 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,642,444 | $114,232 |
| BAKER BROS. ADVISORS LP | 1,432,529 | $99,632 |
| PRINCIPAL FINANCIAL GROUP INC | 1,284,210 | $89,317 |
| Casdin Capital, LLC | 1,175,000 | $81,721 |
| ORBIMED ADVISORS LLC | 1,161,803 | $80,803 |
| Siren, L.L.C. | 1,078,698 | $75,023 |
| TCG Crossover Management, LLC | 920,857 | $64,046 |
| Capitolis Liquid Global Markets LLC | 878,300 | $61,086 |
| FRANKLIN RESOURCES INC | 870,582 | $60,549 |
| ALLIANCEBERNSTEIN L.P. | 848,851 | $59,038 |
| DEUTSCHE BANK AG\ | 841,162 | $58,503 |
| CITADEL ADVISORS LLC | 772,518 | $53,729 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 767,993 | $53,414 |
| Rock Springs Capital Management LP | 748,236 | $52,040 |
| PACIFIC HEIGHTS ASSET MANAGEMENT LLC | 700,000 | $48,685 |
| Logos Global Management LP | 600,000 | $41,730 |
| AMERICAN CENTURY COMPANIES INC | 506,959 | $35,259 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 467,800 | $32,535 |
| FARALLON CAPITAL MANAGEMENT LLC | 454,000 | $31,576 |
| BlackRock, Inc. | 430,082 | $29,912 |
| STEMPOINT CAPITAL LP | 351,073 | $24,417 |
| EcoR1 Capital, LLC | 334,380 | $23,256 |
| AMERIPRISE FINANCIAL INC | 285,518 | $19,858 |
| ArrowMark Colorado Holdings LLC | 271,213 | $18,863 |
| HSG Holding Ltd | 266,062 | $24,443 |
| NATIONAL BANK OF CANADA /FI/ | 265,400 | $18,459 |
| abrdn plc | 264,869 | $18,422 |
| Catalio Capital Management, LP | 252,901 | $17,589 |
| Capricorn Fund Managers Ltd | 252,600 | $17,568 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 250,000 | $17,388 |
| Monashee Investment Management LLC | 225,000 | $15,649 |
| GOLDMAN SACHS GROUP INC | 224,332 | $15,602 |
| BALYASNY ASSET MANAGEMENT L.P. | 216,199 | $15,037 |
| UBS Group AG | 202,477 | $14,082 |
| Sio Capital Management, LLC | 201,500 | $14,014 |
| HighVista Strategies LLC | 193,001 | $13,423 |
| TD Asset Management Inc | 174,674 | $12,149 |
| MARSHALL WACE, LLP | 168,584 | $11,725 |
| MILLENNIUM MANAGEMENT LLC | 152,560 | $10,611 |
| Rhenman & Partners Asset Management AB | 147,600 | $10,266 |
| JANE STREET GROUP, LLC | 147,217 | $10,239 |
| Bellevue Group AG | 145,167 | $10,096 |
| Eversept Partners, LP | 127,561 | $8,872 |
| Woodline Partners LP | 123,902 | $8,617 |
| RENAISSANCE TECHNOLOGIES LLC | 115,200 | $8,012 |
| Alyeska Investment Group, L.P. | 115,000 | $7,998 |
| Jefferies Financial Group Inc. | 102,993 | $7,163 |
| RTW INVESTMENTS, LP | 100,000 | $6,955 |
| Jain Global LLC | 99,996 | $6,955 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 99,617 | $6,928 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 96,387 | $6,533 |
| TWO SIGMA INVESTMENTS, LP | 95,543 | $6,645 |
| SummitTX Capital, L.P. | 94,671 | $6,584 |
| NEXTBio Capital Management LP | 94,443 | $6,569 |
| SIMPLEX TRADING, LLC | 92,668 | $6,445 |
| Birchview Capital, LP | 90,000 | $6,260 |
| Soleus Capital Management, L.P. | 90,000 | $6,260 |
| B Group, Inc. | 90,000 | $6,260 |
| Trexquant Investment LP | 89,945 | $6,256 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 87,874 | $6,112 |
| Brevan Howard Capital Management LP | 86,310 | $5,957 |
| PEREGRINE CAPITAL MANAGEMENT LLC | 84,324 | $5,865 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 83,052 | $5,776 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 82,645 | $5,748 |
| Verition Fund Management LLC | 78,149 | $5,435 |
| Boxer Capital Management, LLC | 75,000 | $5,216 |
| PFM Health Sciences, LP | 68,248 | $4,747 |
| Susquehanna Portfolio Strategies, LLC | 68,089 | $4,736 |
| Burkehill Global Management, LP | 60,000 | $4,173 |
| Longaeva Partners L.P. | 60,000 | $4,173 |
| BANQUE PICTET & CIE SA | 59,881 | $4,165 |
| OSAIC HOLDINGS, INC. | 59,238 | $4,120 |
| Voya Investment Management LLC | 55,300 | $3,846 |
| GEODE CAPITAL MANAGEMENT, LLC | 55,148 | $3,836 |
| Parkman Healthcare Partners LLC | 55,000 | $3,825 |
| BANK OF MONTREAL /CAN/ | 54,341 | $3,683 |
| Integral Health Asset Management, LLC | 50,000 | $3,478 |
| SEVEN GRAND MANAGERS, LLC | 50,000 | $3,478 |
| Buckland Partners Management Co LLC | 50,000 | $3,478 |
| ALPS ADVISORS INC | 49,726 | $3,458 |
| Pier Capital, LLC | 48,757 | $3,391 |
| FLAX POND CAPITAL, LLC | 48,721 | $3,389 |
| STATE STREET CORP | 48,224 | $3,354 |
| ANTIPODES PARTNERS Ltd | 46,291 | $3,246 |
| RAYMOND JAMES FINANCIAL INC | 44,388 | $3,087 |
| Mariner, LLC | 44,155 | $3,071 |
| Headlands Technologies LLC | 43,729 | $3,041 |
| SPHERA FUNDS MANAGEMENT LTD. | 41,000 | $2,852 |
| ACT CAPITAL MANAGEMENT, LLC | 38,500 | $2,678 |
| EAM Investors, LLC | 38,054 | $2,647 |
| DAFNA Capital Management LLC | 37,000 | $2,573 |
| TUDOR INVESTMENT CORP ET AL | 35,053 | $2,438 |
| 95 other institutions | 760,941 | $48,986 |