| BAKER BROS. ADVISORS LP | 36,391,063 | $636,480 |
| FMR LLC | 13,360,807 | $233,681 |
| VANGUARD GROUP INC | 11,177,220 | $195,490 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 9,371,415 | $164 |
| BlackRock, Inc. | 9,361,921 | $163,740 |
| STATE STREET CORP | 6,636,361 | $116,070 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,147,480 | $55,063 |
| CITADEL ADVISORS LLC | 2,475,708 | $43,300 |
| Polymer Capital Management (HK) LTD | 1,421,155 | $24,856 |
| Pictet Asset Management Holding SA | 1,383,775 | $24,382 |
| NORGES BANK | 1,373,943 | $24,030 |
| APEIRON CAPITAL Ltd | 1,309,241 | $22,899 |
| TD Asset Management Inc | 1,205,272 | $21,080 |
| abrdn plc | 927,171 | $16,216 |
| MORGAN STANLEY | 926,579 | $16,206 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 892,629 | $15,612 |
| UBS Group AG | 870,719 | $15,229 |
| Squarepoint Ops LLC | 715,410 | $12,513 |
| Rock Springs Capital Management LP | 710,000 | $12,418 |
| TWO SIGMA INVESTMENTS, LP | 578,248 | $10,114 |
| NOMURA HOLDINGS INC | 542,234 | $9,484 |
| Candriam S.C.A. | 540,662 | $9,457 |
| NORTHERN TRUST CORP | 528,487 | $9,243 |
| GOLDMAN SACHS GROUP INC | 485,566 | $8,493 |
| BANK OF AMERICA CORP /DE/ | 477,393 | $8,350 |
| MILLENNIUM MANAGEMENT LLC | 469,017 | $8,203 |
| Invesco Ltd. | 461,301 | $8,068 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 440,953 | $7,712 |
| TUDOR INVESTMENT CORP ET AL | 423,084 | $7,400 |
| D. E. Shaw & Co., Inc. | 415,284 | $7,263 |
| DIMENSIONAL FUND ADVISORS LP | 376,563 | $6,586 |
| QVT Financial LP | 360,524 | $6,306 |
| AQR CAPITAL MANAGEMENT LLC | 357,870 | $6,195 |
| Sculptor Capital LP | 356,900 | $6,242 |
| Bank of New York Mellon Corp | 353,756 | $6,187 |
| BARCLAYS PLC | 338,390 | $5,918 |
| Skandinaviska Enskilda Banken AB (publ) | 338,363 | $5,915 |
| READYSTATE ASSET MANAGEMENT LP | 306,184 | $5,355 |
| Rafferty Asset Management, LLC | 287,810 | $5,034 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 251,391 | $4,397 |
| DEUTSCHE BANK AG\ | 237,788 | $4,159 |
| Nuveen, LLC | 232,642 | $4,069 |
| Verition Fund Management LLC | 228,990 | $4,005 |
| Woodline Partners LP | 214,507 | $3,752 |
| GRIFFIN ASSET MANAGEMENT, INC. | 195,547 | $3,420 |
| WELLS FARGO & COMPANY/MN | 130,886 | $2,289 |
| CITIGROUP INC | 129,926 | $2,272 |
| RHUMBLINE ADVISERS | 121,341 | $2,122 |
| China Universal Asset Management Co., Ltd. | 121,307 | $2,122 |
| CAPITAL FUND MANAGEMENT S.A. | 113,391 | $1,983 |
| Cerity Partners LLC | 112,878 | $1,974 |
| Voya Investment Management LLC | 112,437 | $1,967 |
| PROFUND ADVISORS LLC | 103,761 | $1,815 |
| Jefferies Financial Group Inc. | 100,000 | $1,749 |
| Illinois Municipal Retirement Fund | 99,367 | $1,738 |
| HSBC HOLDINGS PLC | 98,766 | $1,723 |
| NEOS Investment Management LLC | 97,217 | $1,700 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 96,009 | $1,679 |
| TEMA ETFS LLC | 95,782 | $1,675 |
| BANK OF MONTREAL /CAN/ | 95,371 | $1,668 |
| STATE OF WISCONSIN INVESTMENT BOARD | 92,882 | $1,625 |
| ADAR1 Capital Management, LLC | 91,869 | $1,607 |
| Focus Partners Wealth | 88,448 | $1,547 |
| DARK FOREST CAPITAL MANAGEMENT LP | 87,069 | $1,523 |
| AXQ CAPITAL, LP | 81,519 | $1,426 |
| UBS ASSET MANAGEMENT AMERICAS INC | 79,626 | $1,393 |
| SECTORAL ASSET MANAGEMENT INC | 79,625 | $1,393 |
| LMR Partners LLP | 75,200 | $1,315 |
| Polianta Ltd | 74,700 | $1 |
| Mariner, LLC | 73,497 | $1,285 |
| JPMORGAN CHASE & CO | 67,422 | $1,179 |
| DnB Asset Management AS | 61,061 | $1,068 |
| Aquatic Capital Management LLC | 59,945 | $1,048 |
| Assenagon Asset Management S.A. | 59,621 | $1,043 |
| Wealth Management Partners, LLC | 59,430 | $1,039 |
| Farther Finance Advisors, LLC | 57,282 | $1,002 |
| AMERIPRISE FINANCIAL INC | 54,012 | $945 |
| NEW YORK STATE COMMON RETIREMENT FUND | 53,777 | $941 |
| Police & Firemen's Retirement System of New Jersey | 52,619 | $920 |
| BALYASNY ASSET MANAGEMENT L.P. | 50,298 | $880 |
| GUGGENHEIM CAPITAL LLC | 49,798 | $871 |
| Treasurer of the State of North Carolina | 48,940 | $1 |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 41,734 | $730 |
| Beacon Pointe Advisors, LLC | 39,611 | $693 |
| Mirae Asset Global Investments Co., Ltd. | 37,991 | $664 |
| LEVIN CAPITAL STRATEGIES, L.P. | 37,676 | $659 |
| Handelsbanken Fonder AB | 37,600 | $1 |
| BNP PARIBAS ARBITRAGE, SA | 37,084 | $649 |
| Vident Advisory, LLC | 35,880 | $628 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 35,158 | $615 |
| ProShare Advisors LLC | 32,881 | $575 |
| GROUP ONE TRADING, L.P. | 31,410 | $549 |
| IMC-Chicago, LLC | 29,704 | $520 |
| Capstone Capital Management Ltd | 28,190 | $493 |
| FIRST TRUST ADVISORS LP | 28,115 | $492 |
| Legal & General Group Plc | 27,359 | $479 |
| Schonfeld Strategic Advisors LLC | 27,304 | $478 |
| Eurizon Capital SGR S.p.A. | 25,662 | $449 |
| GREAT VALLEY ADVISOR GROUP, INC. | 25,640 | $448 |
| Entropy Technologies, LP | 25,162 | $440 |
| 105 other institutions | 619,437 | $9,974 |