SUPERNUS PHARMACEUTICALS INC

Ticker: SUPN CUSIP: 868459108 Class: EQTY

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q2 2016

Shares 125,000 Value ($000) $2,546 Avg Close $17.74 Range $14.14 - $20.38

Q1 2016

Shares 125,000 Value ($000) $1,906 Avg Close $13.05 Range $9.51 - $15.99

Q4 2015

Shares 420,000 Value ($000) $5,645 Avg Close $15.47 Range $12.54 - $20.39

Q3 2015

Shares 460,000 Value ($000) $6,454 Avg Close $18.59 Range $13.32 - $23.30

Q2 2015

Shares 535,000 Value ($000) $9,084 Avg Close $14.23 Range $11.11 - $18.55

Q1 2015

Shares 535,000 Value ($000) $6,468 Avg Close $9.45 Range $7.97 - $12.38

Q4 2014

Shares 350,000 Value ($000) $2,905 Avg Close $8.40 Range $7.31 - $9.53

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2016	125,000	$2,546	$17.74	$14.14 - $20.38
Q1 2016	125,000	$1,906	$13.05	$9.51 - $15.99
Q4 2015	420,000	$5,645	$15.47	$12.54 - $20.39
Q3 2015	460,000	$6,454	$18.59	$13.32 - $23.30
Q2 2015	535,000	$9,084	$14.23	$11.11 - $18.55
Q1 2015	535,000	$6,468	$9.45	$7.97 - $12.38
Q4 2014	350,000	$2,905	$8.40	$7.31 - $9.53