| MILLENNIUM MANAGEMENT LLC | 721,266 | $16,301 |
| VR Adviser, LLC | 632,931 | $14,304 |
| STEMPOINT CAPITAL LP | 619,766 | $12,672 |
| BRAIDWELL LP | 470,000 | $10,622 |
| Spruce Street Capital LP | 432,040 | $9,764 |
| Boxer Capital Management, LLC | 416,150 | $9,405 |
| 5AM Venture Management, LLC | 387,500 | $8,758 |
| Kalehua Capital Management LLC | 385,178 | $1,886 |
| VANGUARD GROUP INC | 319,236 | $7,215 |
| Vivo Capital, LLC | 260,000 | $5,876 |
| Woodline Partners LP | 230,572 | $5,211 |
| Nantahala Capital Management, LLC | 229,527 | $5,187 |
| BALYASNY ASSET MANAGEMENT L.P. | 190,489 | $4,305 |
| ACUTA CAPITAL PARTNERS, LLC | 178,415 | $4,032 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 157,323 | $3,556 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 133,207 | $3,010 |
| Stonepine Capital Management, LLC | 113,631 | $2,568 |
| Empery Asset Management, LP | 103,974 | $2,350 |
| FRED ALGER MANAGEMENT, LLC | 99,560 | $2,250 |
| Eversept Partners, LP | 95,286 | $2,153 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 88,653 | $2,004 |
| Euclidean Capital LLC | 87,696 | $1,982 |
| Schonfeld Strategic Advisors LLC | 74,645 | $1,687 |
| GEODE CAPITAL MANAGEMENT, LLC | 66,995 | $1,515 |
| Ikarian Capital, LLC | 65,788 | $1,487 |
| AMERIPRISE FINANCIAL INC | 65,688 | $1,485 |
| ArrowMark Colorado Holdings LLC | 55,123 | $1,246 |
| 683 Capital Management, LLC | 41,999 | $949 |
| Walleye Capital LLC | 41,041 | $928 |
| MORGAN STANLEY | 36,961 | $835 |
| BANK OF AMERICA CORP /DE/ | 29,608 | $669 |
| JANE STREET GROUP, LLC | 27,622 | $624 |
| BlackRock, Inc. | 26,118 | $590 |
| GOLDMAN SACHS GROUP INC | 25,823 | $584 |
| STATE STREET CORP | 24,326 | $550 |
| LMR Partners LLP | 23,557 | $532 |
| RENAISSANCE TECHNOLOGIES LLC | 22,626 | $511 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,715 | $0 |
| Brevan Howard Capital Management LP | 18,921 | $428 |
| BOOTHBAY FUND MANAGEMENT, LLC | 18,307 | $414 |
| Quadrature Capital Ltd | 14,802 | $335 |
| CITADEL ADVISORS LLC | 14,740 | $333 |
| OMERS ADMINISTRATION Corp | 13,700 | $310 |
| NORTHERN TRUST CORP | 13,530 | $306 |
| IEQ CAPITAL, LLC | 13,471 | $304 |
| MARSHALL WACE, LLP | 10,939 | $247 |
| Alyeska Investment Group, L.P. | 10,188 | $230 |
| Persistent Asset Partners Ltd | 4,359 | $99 |
| BNP PARIBAS ARBITRAGE, SA | 2,520 | $57 |
| ACADIAN ASSET MANAGEMENT LLC | 1,508 | $0 |
| China Universal Asset Management Co., Ltd. | 1,500 | $34 |
| CITIGROUP INC | 1,062 | $24 |
| ROYAL BANK OF CANADA | 65 | $1 |
| UBS Group AG | 59 | $1 |