SYNERGY PHARMACEUTICALS DEL

CUSIP: 871639308 Class: COM

STATE OF MICHIGAN RETIREMENT SYSTEM's Holding History (CIK: 0000762152)

Note: Option positions (PUT/CALL) are excluded.

Q1 2018
Shares 45,000 Value ($000) $82 Avg Close — Range —
Q4 2017
Shares 45,000 Value ($000) $100 Avg Close — Range —
Q3 2017
Shares 45,000 Value ($000) $131 Avg Close — Range —
Q2 2017
Shares 45,000 Value ($000) $200 Avg Close — Range —
Q1 2017
Shares 50,000 Value ($000) $233 Avg Close — Range —
Q4 2016
Shares 50,000 Value ($000) $305 Avg Close — Range —
Q3 2016
Shares 40,000 Value ($000) $220 Avg Close — Range —
Q2 2016
Shares 40,000 Value ($000) $152 Avg Close — Range —