SYNERGY PHARMACEUTICALS DEL

CUSIP: 871639308 Class: COM

RENAISSANCE TECHNOLOGIES LLC's Holding History (CIK: 0001037389)

Note: Option positions (PUT/CALL) are excluded.

Q1 2017
Shares 56,534 Value ($000) $263 Avg Close — Range —
Q4 2015
Shares 397,600 Value ($000) $2,254 Avg Close — Range —
Q4 2014
Shares 162,095 Value ($000) $494 Avg Close — Range —
Q1 2014
Shares 197,390 Value ($000) $1,048 Avg Close — Range —
Q4 2013
Shares 208,600 Value ($000) $1,174 Avg Close — Range —