SYNERGY PHARMACEUTICALS DEL

CUSIP: 871639308 Class: COM

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q3 2017
Shares 13,621,443 Value ($000) $39,502 Avg Close — Range —
Q2 2017
Shares 21,153,343 Value ($000) $94,132 Avg Close — Range —
Q1 2017
Shares 21,153,343 Value ($000) $98,575 Avg Close — Range —
Q4 2016
Shares 18,241,398 Value ($000) $111,090 Avg Close — Range —
Q3 2016
Shares 5,976,648 Value ($000) $32,931 Avg Close — Range —
Q2 2016
Shares 5,976,648 Value ($000) $22,711 Avg Close — Range —
Q1 2016
Shares 2,276,648 Value ($000) $6,284 Avg Close — Range —
Q4 2015
Shares 2,276,648 Value ($000) $12,909 Avg Close — Range —
Q3 2015
Shares 2,276,648 Value ($000) $12,066 Avg Close — Range —
Q2 2015
Shares 3,121,148 Value ($000) $25,906 Avg Close — Range —
Q1 2015
Shares 3,121,148 Value ($000) $14,420 Avg Close — Range —