SYNDAX PHARMACEUTICALS INC

Ticker: SNDX CUSIP: 87164F105 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,146,936 Value ($000) $24,097 Avg Close $17.45 Range $12.99 - $22.73

Q3 2025

Shares 712,659 Value ($000) $10,964 Avg Close $13.09 Range $8.59 - $17.24

Q2 2025

Shares 556,971 Value ($000) $5,216 Avg Close $11.01 Range $8.58 - $14.24

Q1 2025

Shares 780,009 Value ($000) $9,582 Avg Close $14.10 Range $12.06 - $16.95

Q4 2024

Shares 669,823 Value ($000) $8,855 Avg Close $17.11 Range $12.40 - $22.50

Q3 2024

Shares 886,494 Value ($000) $17,065 Avg Close $20.66 Range $17.34 - $25.07

Q2 2024

Shares 930,947 Value ($000) $19,112 Avg Close $20.93 Range $18.65 - $24.38

Q1 2024

Shares 718,552 Value ($000) $17,102 Avg Close $22.30 Range $19.58 - $25.34

Q4 2023

Shares 535,938 Value ($000) $11,582 Avg Close $15.37 Range $11.21 - $21.84

Q3 2023

Shares 431,565 Value ($000) $6,266 Avg Close $18.92 Range $12.85 - $23.55

Q1 2023

Shares 69,169 Value ($000) $1,461 Avg Close $24.88 Range $20.01 - $29.86

Q2 2022

Shares 94,474 Value ($000) $1,818 Avg Close $16.66 Range $13.27 - $19.91

Q1 2022

Shares 224,058 Value ($000) $3,894 Avg Close $16.84 Range $14.56 - $22.27

Q4 2021

Shares 322,720 Value ($000) $7,064 Avg Close $18.48 Range $14.76 - $22.71

Q3 2021

Shares 109,980 Value ($000) $2,102 Avg Close $16.66 Range $13.58 - $20.32

Q2 2021

Shares 112,339 Value ($000) $1,929 Avg Close $18.32 Range $13.02 - $25.46

Q1 2021

Shares 241,414 Value ($000) $5,398 Avg Close $22.59 Range $19.05 - $25.68

Q4 2020

Shares 594,871 Value ($000) $13,230 Avg Close $20.74 Range $13.92 - $27.85

Q3 2020

Shares 226,689 Value ($000) $3,346 Avg Close $15.24 Range $13.04 - $17.99

Q2 2020

Shares 354,811 Value ($000) $5,258 Avg Close $15.23 Range $8.72 - $21.97

Q1 2020

Shares 64,805 Value ($000) $711 Avg Close $9.38 Range $6.32 - $12.27

Q4 2019

Shares 56,194 Value ($000) $493 Avg Close $7.34 Range $5.35 - $9.47

Q3 2019

Shares 17,735 Value ($000) $132 Avg Close $9.11 Range $7.45 - $11.11

Q4 2018

Shares 13,487 Value ($000) $60 Avg Close $5.48 Range $3.39 - $9.15

Q3 2018

Shares 23,065 Value ($000) $186 Avg Close $7.13 Range $6.10 - $8.24

Q4 2017

Shares 30,930 Value ($000) $271 Avg Close $9.90 Range $7.70 - $13.48

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,146,936	$24,097	$17.45	$12.99 - $22.73
Q3 2025	712,659	$10,964	$13.09	$8.59 - $17.24
Q2 2025	556,971	$5,216	$11.01	$8.58 - $14.24
Q1 2025	780,009	$9,582	$14.10	$12.06 - $16.95
Q4 2024	669,823	$8,855	$17.11	$12.40 - $22.50
Q3 2024	886,494	$17,065	$20.66	$17.34 - $25.07
Q2 2024	930,947	$19,112	$20.93	$18.65 - $24.38
Q1 2024	718,552	$17,102	$22.30	$19.58 - $25.34
Q4 2023	535,938	$11,582	$15.37	$11.21 - $21.84
Q3 2023	431,565	$6,266	$18.92	$12.85 - $23.55
Q1 2023	69,169	$1,461	$24.88	$20.01 - $29.86
Q2 2022	94,474	$1,818	$16.66	$13.27 - $19.91
Q1 2022	224,058	$3,894	$16.84	$14.56 - $22.27
Q4 2021	322,720	$7,064	$18.48	$14.76 - $22.71
Q3 2021	109,980	$2,102	$16.66	$13.58 - $20.32
Q2 2021	112,339	$1,929	$18.32	$13.02 - $25.46
Q1 2021	241,414	$5,398	$22.59	$19.05 - $25.68
Q4 2020	594,871	$13,230	$20.74	$13.92 - $27.85
Q3 2020	226,689	$3,346	$15.24	$13.04 - $17.99
Q2 2020	354,811	$5,258	$15.23	$8.72 - $21.97
Q1 2020	64,805	$711	$9.38	$6.32 - $12.27
Q4 2019	56,194	$493	$7.34	$5.35 - $9.47
Q3 2019	17,735	$132	$9.11	$7.45 - $11.11
Q4 2018	13,487	$60	$5.48	$3.39 - $9.15
Q3 2018	23,065	$186	$7.13	$6.10 - $8.24
Q4 2017	30,930	$271	$9.90	$7.70 - $13.48