| BlackRock, Inc. | 8,239,002 | $173,101 |
| Kynam Capital Management, LP | 8,050,959 | $169,151 |
| VANGUARD GROUP INC | 6,230,334 | $130,899 |
| GOLDMAN SACHS GROUP INC | 5,695,375 | $119,660 |
| Point72 Asset Management, L.P. | 4,882,053 | $102,572 |
| BANK OF AMERICA CORP /DE/ | 4,710,746 | $98,973 |
| STATE STREET CORP | 4,596,552 | $96,574 |
| Eversept Partners, LP | 3,314,408 | $69,636 |
| FRANKLIN RESOURCES INC | 2,421,666 | $50,879 |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,350,000 | $49,374 |
| Hood River Capital Management LLC | 2,316,553 | $48,671 |
| Soleus Capital Management, L.P. | 2,247,110 | $47,212 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,090,932 | $43,938 |
| Elmind Capital, LP | 1,855,000 | $38,974 |
| Ensign Peak Advisors, Inc | 1,598,544 | $33,585 |
| Nuveen, LLC | 1,483,002 | $31,158 |
| BNP Paribas Investment Partners S.A. | 1,375,681 | $29 |
| STEMPOINT CAPITAL LP | 1,339,379 | $28,140 |
| MPM BioImpact LLC | 1,337,702 | $28,105 |
| Aisling Capital Management LP | 1,316,806 | $27,666 |
| Woodline Partners LP | 1,250,668 | $26,277 |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,238,196 | $26,014 |
| D. E. Shaw & Co., Inc. | 1,219,609 | $25,624 |
| Catalio Capital Management, LP | 1,196,807 | $25,145 |
| TWO SIGMA INVESTMENTS, LP | 1,146,936 | $24,097 |
| Bank of New York Mellon Corp | 1,094,151 | $22,988 |
| MORGAN STANLEY | 1,075,501 | $22,596 |
| ALGERT GLOBAL LLC | 928,088 | $19 |
| AQR CAPITAL MANAGEMENT LLC | 925,974 | $19,455 |
| Candriam S.C.A. | 925,332 | $19,442 |
| Palo Alto Investors LP | 794,507 | $16,693 |
| SPHERA FUNDS MANAGEMENT LTD. | 762,563 | $16,021 |
| JANE STREET GROUP, LLC | 748,920 | $15,735 |
| NORTHERN TRUST CORP | 728,921 | $15,315 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 727,424 | $15,283 |
| APIS CAPITAL ADVISORS, LLC | 724,000 | $15,211 |
| UBS Group AG | 716,219 | $15,048 |
| Qube Research & Technologies Ltd | 688,137 | $14,458 |
| Prosight Management, LP | 665,000 | $13,972 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 642,899 | $13,507 |
| TWO SIGMA ADVISERS, LP | 632,752 | $13,294 |
| Parkman Healthcare Partners LLC | 574,023 | $12,060 |
| ExodusPoint Capital Management, LP | 554,761 | $11,656 |
| RENAISSANCE TECHNOLOGIES LLC | 544,800 | $11,446 |
| Brevan Howard Capital Management LP | 515,129 | $10,823 |
| Rhenman & Partners Asset Management AB | 487,000 | $10,232 |
| Knott David M Jr | 415,000 | $8,719 |
| JPMORGAN CHASE & CO | 378,504 | $7,952 |
| abrdn plc | 372,792 | $7,832 |
| Granahan Investment Management, LLC | 366,793 | $7,706 |
| BARCLAYS PLC | 314,672 | $6,611 |
| Pale Fire Capital SE | 284,460 | $5,977 |
| AMERIPRISE FINANCIAL INC | 282,587 | $5,937 |
| DAFNA Capital Management LLC | 277,855 | $5,838 |
| SECTOR GAMMA AS | 252,062 | $5,296 |
| PFM Health Sciences, LP | 242,967 | $5,105 |
| CAPITAL FUND MANAGEMENT S.A. | 233,871 | $4,914 |
| CANADA PENSION PLAN INVESTMENT BOARD | 229,600 | $4,824 |
| Pinnacle Financial Partners, Inc. | 206,601 | $4,341 |
| Integral Health Asset Management, LLC | 200,000 | $4,202 |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 200,000 | $4,202 |
| CITADEL ADVISORS LLC | 184,003 | $3,866 |
| Hennion & Walsh Asset Management, Inc. | 183,802 | $3,862 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 180,000 | $3,782 |
| Hudson Bay Capital Management LP | 165,000 | $3,467 |
| Jump Financial, LLC | 163,915 | $3,444 |
| Rafferty Asset Management, LLC | 161,943 | $3,402 |
| Swiss National Bank | 161,400 | $3,391 |
| WELLS FARGO & COMPANY/MN | 160,850 | $3,379 |
| Invesco Ltd. | 160,525 | $3,373 |
| SEI INVESTMENTS CO | 159,638 | $3,354 |
| Y-Intercept (Hong Kong) Ltd | 155,916 | $3,276 |
| UBS ASSET MANAGEMENT AMERICAS INC | 142,407 | $2,992 |
| Atom Investors LP | 141,666 | $2,976 |
| FMR LLC | 140,560 | $2,953 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 137,629 | $2,892 |
| Velan Capital Investment Management LP | 130,000 | $2,731 |
| SG Americas Securities, LLC | 129,227 | $3 |
| PANAGORA ASSET MANAGEMENT INC | 125,099 | $2,628 |
| Voss Capital, LLC | 125,000 | $2,626 |
| RHUMBLINE ADVISERS | 118,799 | $2,496 |
| Yelin Lapidot Holdings Management Ltd. | 108,377 | $2,277 |
| NEOS Investment Management LLC | 101,553 | $2,134 |
| TEMA ETFS LLC | 100,053 | $2,102 |
| Ishara Investments LP | 100,000 | $2,101 |
| IEQ CAPITAL, LLC | 99,876 | $2,098 |
| Torray Investment Partners LLC | 97,802 | $2,055 |
| ALLIANCEBERNSTEIN L.P. | 94,880 | $1,993 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 94,829 | $2 |
| Russell Investments Group, Ltd. | 89,639 | $1,883 |
| Trexquant Investment LP | 87,514 | $1,839 |
| Legal & General Group Plc | 78,236 | $1,644 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 78,199 | $1,643 |
| STIFEL FINANCIAL CORP | 75,914 | $1,595 |
| DARK FOREST CAPITAL MANAGEMENT LP | 72,703 | $1,527 |
| DEUTSCHE BANK AG\ | 66,608 | $1,399 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 65,280 | $874 |
| SECTORAL ASSET MANAGEMENT INC | 61,200 | $1,286 |
| PROFUND ADVISORS LLC | 60,038 | $1,261 |
| Mariner, LLC | 54,987 | $1,155 |
| 127 other institutions | 2,063,286 | $40,781 |