SYROS PHARMACEUTICALS INC

CUSIP: 87184Q107 Class: COM

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q1 2018
Shares 74,074 Value ($000) $961 Avg Close — Range —
Q4 2017
Shares 74,074 Value ($000) $720 Avg Close — Range —
Q3 2017
Shares 116,574 Value ($000) $1,716 Avg Close — Range —
Q2 2017
Shares 109,500 Value ($000) $1,762 Avg Close — Range —
Q1 2017
Shares 25,149 Value ($000) $400 Avg Close — Range —