| BlackRock, Inc. | 3,790,557 | $310,371 |
| RTW INVESTMENTS, LP | 3,335,320 | $273,096 |
| Deep Track Capital, LP | 3,004,034 | $245,970 |
| Paradigm Biocapital Advisors LP | 2,562,154 | $209,789 |
| VANGUARD GROUP INC | 2,399,560 | $196,476 |
| JENNISON ASSOCIATES LLC | 2,230,069 | $182,598 |
| MORGAN STANLEY | 2,040,742 | $167,096 |
| JANUS HENDERSON GROUP PLC | 1,930,325 | $158,062 |
| TANG CAPITAL MANAGEMENT LLC | 1,188,624 | $97,325 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,172,427 | $95,998 |
| Assenagon Asset Management S.A. | 1,127,730 | $92,339 |
| Invesco Ltd. | 1,012,357 | $82,892 |
| GEODE CAPITAL MANAGEMENT, LLC | 947,763 | $77,616 |
| STATE STREET CORP | 929,059 | $76,071 |
| LORD, ABBETT & CO. LLC | 855,645 | $70 |
| BANK OF AMERICA CORP /DE/ | 758,106 | $62,074 |
| Frazier Life Sciences Management, L.P. | 728,644 | $59,661 |
| FMR LLC | 647,114 | $52,986 |
| D. E. Shaw & Co., Inc. | 615,156 | $50,369 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 584,686 | $47,874 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 518,780 | $42 |
| TORONTO DOMINION BANK | 510,253 | $41,780 |
| Clearbridge Investments, LLC | 506,089 | $41,439 |
| Ensign Peak Advisors, Inc | 474,050 | $38,815 |
| LOOMIS SAYLES & CO L P | 441,873 | $36,181 |
| Artisan Partners Limited Partnership | 436,576 | $35,747 |
| Qube Research & Technologies Ltd | 401,241 | $32,854 |
| GOLDMAN SACHS GROUP INC | 378,704 | $31,008 |
| BNP PARIBAS ARBITRAGE, SA | 356,105 | $29,158 |
| NORTHERN TRUST CORP | 342,486 | $28,043 |
| FRANKLIN RESOURCES INC | 337,016 | $27,595 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 333,111 | $27,275 |
| TimesSquare Capital Management, LLC | 332,446 | $27,221 |
| MPM BioImpact LLC | 328,869 | $26,928 |
| Nuveen, LLC | 322,527 | $26,409 |
| Rock Springs Capital Management LP | 260,344 | $21,317 |
| Cormorant Asset Management, LP | 250,000 | $20,470 |
| Integral Health Asset Management, LLC | 200,000 | $16,376 |
| Connor, Clark & Lunn Investment Management Ltd. | 173,275 | $14,188 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 161,830 | $13,251 |
| ORBIMED ADVISORS LLC | 154,400 | $12,642 |
| Russell Investments Group, Ltd. | 153,760 | $12,590 |
| CANADA PENSION PLAN INVESTMENT BOARD | 151,100 | $12,372 |
| Allspring Global Investments Holdings, LLC | 130,380 | $10,531 |
| Jump Financial, LLC | 128,087 | $10,488 |
| WELLS FARGO & COMPANY/MN | 119,058 | $9,748 |
| Jefferies Financial Group Inc. | 118,810 | $9,728 |
| DEUTSCHE BANK AG\ | 118,229 | $9,681 |
| NORGES BANK | 117,592 | $9,628 |
| MILLENNIUM MANAGEMENT LLC | 117,004 | $9,580 |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 114,460 | $9,372 |
| FIRST TRUST ADVISORS LP | 111,770 | $9,152 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 109,857 | $8,995 |
| Bank of New York Mellon Corp | 107,760 | $8,823 |
| Woodline Partners LP | 100,154 | $8,201 |
| Sands Capital Ventures, LLC | 85,000 | $6,960 |
| BARCLAYS PLC | 80,784 | $6,615 |
| Squadron Capital Management LLC | 80,000 | $6,550 |
| Voleon Capital Management LP | 77,375 | $6,335 |
| EAM Investors, LLC | 72,922 | $5,971 |
| COMMONWEALTH EQUITY SERVICES, LLC | 68,295 | $5,592 |
| UBS Group AG | 66,899 | $5,478 |
| GordonMD Global Investments LP | 66,680 | $5,460 |
| UBS ASSET MANAGEMENT AMERICAS INC | 66,335 | $5,432 |
| Lisanti Capital Growth, LLC | 64,341 | $5,268 |
| RENAISSANCE TECHNOLOGIES LLC | 64,100 | $5,249 |
| TD Asset Management Inc | 64,012 | $5,241 |
| PDT Partners, LLC | 63,026 | $5,161 |
| Swiss National Bank | 62,433 | $5,112 |
| JPMORGAN CHASE & CO | 56,646 | $4,638 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 55,283 | $4,543 |
| Trexquant Investment LP | 54,546 | $4,466 |
| HighVista Strategies LLC | 53,564 | $4,386 |
| CITIGROUP INC | 51,971 | $4,255 |
| ExodusPoint Capital Management, LP | 51,487 | $4,216 |
| Public Sector Pension Investment Board | 50,000 | $4,094 |
| FEDERATED HERMES, INC. | 49,289 | $4,036 |
| RHUMBLINE ADVISERS | 47,080 | $3,855 |
| Baird Financial Group, Inc. | 46,928 | $3,842 |
| ALGERT GLOBAL LLC | 45,985 | $4 |
| SEI INVESTMENTS CO | 43,344 | $3,549 |
| NEW YORK STATE COMMON RETIREMENT FUND | 43,155 | $3,534 |
| CAXTON ASSOCIATES LLP | 40,955 | $3,353 |
| ALLIANCEBERNSTEIN L.P. | 40,654 | $3,329 |
| Walleye Capital LLC | 40,273 | $3,298 |
| F/M Investments LLC | 39,240 | $3,213 |
| Voya Investment Management LLC | 38,071 | $3,117 |
| Point72 Asset Management, L.P. | 37,628 | $3,081 |
| Pictet Asset Management Holding SA | 37,578 | $3,080 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 36,124 | $2,958 |
| RAYMOND JAMES FINANCIAL INC | 35,649 | $2,919 |
| ALPS ADVISORS INC | 34,755 | $2,846 |
| Calamos Advisors LLC | 34,442 | $2,820 |
| E. Ohman J:or Asset Management AB | 33,323 | $2,728 |
| STATE OF WISCONSIN INVESTMENT BOARD | 31,912 | $2,613 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 31,493 | $2,172 |
| Ikarian Capital, LLC | 31,166 | $2,552 |
| Legal & General Group Plc | 31,096 | $2,546 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,179 | $2,471 |
| Penserra Capital Management LLC | 29,430 | $2 |
| 144 other institutions | 989,858 | $71,541 |