TAYSHA GENE THERAPIES INC

Ticker: TSHA CUSIP: 877619106 Class: Stock

FIRST MANHATTAN CO. LLC.'s Holding History (CIK: 0000728083)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 43,500 Value ($000) $239 Avg Close $4.86 Range $3.10 - $6.02

Q3 2025

Shares 28,500 Value ($000) $93 Avg Close $2.83 Range $2.25 - $3.40

Q2 2025

Shares 28,500 Value ($000) $66 Avg Close $2.17 Range $1.05 - $3.24

Q1 2025

Shares 28,500 Value ($000) $40 Avg Close $1.67 Range $1.17 - $2.07

Q4 2024

Shares 28,500 Value ($000) $49 Avg Close $2.07 Range $1.19 - $3.31

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	43,500	$239	$4.86	$3.10 - $6.02
Q3 2025	28,500	$93	$2.83	$2.25 - $3.40
Q2 2025	28,500	$66	$2.17	$1.05 - $3.24
Q1 2025	28,500	$40	$1.67	$1.17 - $2.07
Q4 2024	28,500	$49	$2.07	$1.19 - $3.31