| RA CAPITAL MANAGEMENT, L.P. | 23,555,648 | $129,556 |
| Avoro Capital Advisors LLC | 21,700,000 | $119,350 |
| BlackRock, Inc. | 18,643,129 | $102,537 |
| MORGAN STANLEY | 18,078,518 | $99,432 |
| RTW INVESTMENTS, LP | 16,398,297 | $90,191 |
| Vestal Point Capital, LP | 13,750,000 | $75,625 |
| GOLDMAN SACHS GROUP INC | 13,692,739 | $75,310 |
| FMR LLC | 13,528,366 | $74,406 |
| VANGUARD GROUP INC | 13,267,805 | $72,973 |
| STATE STREET CORP | 10,790,084 | $59,345 |
| Siren, L.L.C. | 10,129,913 | $55,715 |
| Octagon Capital Advisors LP | 8,859,911 | $48,730 |
| Polar Capital Holdings Plc | 7,931,403 | $43,623 |
| BARCLAYS PLC | 5,539,001 | $30,465 |
| GEODE CAPITAL MANAGEMENT, LLC | 5,387,026 | $29,634 |
| D. E. Shaw & Co., Inc. | 4,013,635 | $22,075 |
| BAKER BROS. ADVISORS LP | 4,004,756 | $22,026 |
| Point72 Asset Management, L.P. | 3,868,682 | $21,278 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 3,722,000 | $20,471 |
| Affinity Asset Advisors, LLC | 3,300,000 | $18,150 |
| MILLENNIUM MANAGEMENT LLC | 3,178,863 | $17,484 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,722,165 | $14,972 |
| ADAR1 Capital Management, LLC | 2,495,809 | $13,727 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,902,978 | $10,466 |
| CITADEL ADVISORS LLC | 1,854,855 | $10,202 |
| NORGES BANK | 1,837,800 | $10,108 |
| B Group, Inc. | 1,800,556 | $9,903 |
| Casdin Capital, LLC | 1,500,000 | $8,250 |
| Invesco Ltd. | 1,332,780 | $7,330 |
| GordonMD Global Investments LP | 1,330,901 | $7,320 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,328,000 | $7,304 |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,270,645 | $6,989 |
| NORTHERN TRUST CORP | 1,237,987 | $6,809 |
| Palo Alto Investors LP | 1,183,195 | $6,508 |
| BANK OF AMERICA CORP /DE/ | 1,152,680 | $6,340 |
| abrdn plc | 1,021,063 | $5,616 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 980,768 | $5,394 |
| EAM Investors, LLC | 823,758 | $4,531 |
| Quantum Private Wealth, LLC | 819,715 | $4,508 |
| SG Americas Securities, LLC | 781,474 | $4 |
| JPMORGAN CHASE & CO | 774,412 | $4,259 |
| Sands Capital Ventures, LLC | 724,873 | $3,987 |
| WELLINGTON MANAGEMENT GROUP LLP | 711,235 | $3,912 |
| Granahan Investment Management, LLC | 703,971 | $3,872 |
| Bank of New York Mellon Corp | 624,367 | $3,434 |
| Nuveen, LLC | 545,286 | $2,999 |
| Woodline Partners LP | 500,000 | $2,750 |
| DIMENSIONAL FUND ADVISORS LP | 490,472 | $2,702 |
| Squarepoint Ops LLC | 471,577 | $2,594 |
| Ally Bridge Group (NY) LLC | 457,132 | $2,514 |
| ACUTA CAPITAL PARTNERS, LLC | 454,827 | $2,502 |
| HRT FINANCIAL LP | 409,254 | $2 |
| UBS Group AG | 383,043 | $2,107 |
| SPHERA FUNDS MANAGEMENT LTD. | 368,146 | $2,025 |
| TWO SIGMA INVESTMENTS, LP | 351,126 | $1,931 |
| Rafferty Asset Management, LLC | 344,784 | $1,896 |
| BOOTHBAY FUND MANAGEMENT, LLC | 309,481 | $1,702 |
| Hennion & Walsh Asset Management, Inc. | 308,457 | $1,697 |
| WELLS FARGO & COMPANY/MN | 305,086 | $1,678 |
| Capricorn Fund Managers Ltd | 300,000 | $1,650 |
| Focus Partners Wealth | 295,516 | $1,625 |
| AMERICAN CENTURY COMPANIES INC | 288,535 | $1,587 |
| Ensign Peak Advisors, Inc | 275,111 | $1,513 |
| Swiss National Bank | 268,800 | $1,478 |
| ORACLE INVESTMENT MANAGEMENT INC | 265,000 | $1,458 |
| NOMURA HOLDINGS INC | 259,339 | $1,426 |
| RHUMBLINE ADVISERS | 257,440 | $1,416 |
| ALPS ADVISORS INC | 224,920 | $1,237 |
| Voya Investment Management LLC | 218,185 | $1,200 |
| GSA CAPITAL PARTNERS LLP | 208,016 | $1 |
| VICTORY CAPITAL MANAGEMENT INC | 195,764 | $1,077 |
| STEMPOINT CAPITAL LP | 182,130 | $1,002 |
| WEXFORD CAPITAL LP | 180,853 | $995 |
| ALLIANCEBERNSTEIN L.P. | 179,640 | $988 |
| Palumbo Wealth Management LLC | 178,007 | $979 |
| BNP PARIBAS ARBITRAGE, SA | 172,482 | $949 |
| RENAISSANCE TECHNOLOGIES LLC | 171,100 | $941 |
| AQR CAPITAL MANAGEMENT LLC | 168,862 | $929 |
| UBS ASSET MANAGEMENT AMERICAS INC | 167,500 | $921 |
| Seven Fleet Capital Management LP | 167,223 | $920 |
| Chicago Partners Investment Group LLC | 166,541 | $776 |
| Privium Fund Management B.V. | 164,900 | $907 |
| JANE STREET GROUP, LLC | 163,146 | $897 |
| DEUTSCHE BANK AG\ | 160,779 | $884 |
| POLEN CAPITAL MANAGEMENT LLC | 156,586 | $861 |
| TWO SIGMA ADVISERS, LP | 139,581 | $768 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 138,580 | $762 |
| Legal & General Group Plc | 133,146 | $732 |
| PROFUND ADVISORS LLC | 128,590 | $707 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 124,975 | $687 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 122,639 | $678 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 121,814 | $1 |
| MetLife Investment Management, LLC | 113,266 | $623 |
| STATE OF WISCONSIN INVESTMENT BOARD | 113,178 | $622 |
| FRANKLIN RESOURCES INC | 108,399 | $596 |
| PRUDENTIAL FINANCIAL INC | 86,730 | $477 |
| INTECH INVESTMENT MANAGEMENT LLC | 71,069 | $391 |
| JANUS HENDERSON GROUP PLC | 69,000 | $378 |
| CANADA PENSION PLAN INVESTMENT BOARD | 68,900 | $379 |
| NEW YORK STATE COMMON RETIREMENT FUND | 67,500 | $371 |
| 93 other institutions | 1,919,181 | $10,287 |