TAYSHA GENE THERAPIES INC

Ticker: TSHA CUSIP: 877619106 Class: Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 139,581 Value ($000) $768 Avg Close $4.86 Range $3.10 - $6.02

Q3 2022

Shares 87,700 Value ($000) $169 Avg Close $3.63 Range $1.68 - $5.09

Q2 2022

Shares 105,800 Value ($000) $394 Avg Close $3.97 Range $2.33 - $7.07

Q1 2022

Shares 136,300 Value ($000) $889 Avg Close $7.48 Range $5.00 - $12.17

Q4 2021

Shares 34,100 Value ($000) $397 Avg Close $15.08 Range $11.12 - $19.54

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	139,581	$768	$4.86	$3.10 - $6.02
Q3 2022	87,700	$169	$3.63	$1.68 - $5.09
Q2 2022	105,800	$394	$3.97	$2.33 - $7.07
Q1 2022	136,300	$889	$7.48	$5.00 - $12.17
Q4 2021	34,100	$397	$15.08	$11.12 - $19.54