TEKLA HEALTHCARE OPPORTUNITI

CUSIP: 879105104 Class: SHS

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q3 2017
Shares 13,156 Value ($000) $244 Avg Close — Range —
Q2 2017
Shares 11,184 Value ($000) $205 Avg Close — Range —
Q4 2016
Shares 11,663 Value ($000) $181 Avg Close — Range —