TETRAPHASE PHARMACEUTICALS I

CUSIP: 88165N105 Class: COMMON STOCK

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 49,500 Value ($000) $2,348 Avg Close — Range —
Q1 2015
Shares 75,000 Value ($000) $2,748 Avg Close — Range —
Q3 2014
Shares 2,365 Value ($000) $47 Avg Close — Range —
Q2 2014
Shares 198,000 Value ($000) $2,671 Avg Close — Range —