TETRAPHASE PHARMACEUTICALS I

CUSIP: 88165N105 Class: COMMON STOCK

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q2 2017
Shares 330,000 Value ($000) $2,353 Avg Close — Range —
Q2 2015
Shares 65,000 Value ($000) $3,084 Avg Close — Range —
Q1 2015
Shares 175,000 Value ($000) $6,412 Avg Close — Range —
Q4 2014
Shares 189,700 Value ($000) $7,533 Avg Close — Range —
Q3 2014
Shares 169,700 Value ($000) $3,385,515 Avg Close — Range —
Q2 2014
Shares 169,700 Value ($000) $2,289 Avg Close — Range —
Q1 2014
Shares 160,000 Value ($000) $1,757 Avg Close — Range —
Q4 2013
Shares 153,500 Value ($000) $1,995,500 Avg Close — Range —