TOBIRA THERAPEUTICS INC

CUSIP: 88883P101 Class: COMMON

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 32,300 Value ($000) $264 Avg Close — Range —
Q4 2015
Shares 187,622 Value ($000) $1,886 Avg Close — Range —
Q3 2015
Shares 137,622 Value ($000) $1,329 Avg Close — Range —
Q2 2015
Shares 137,622 Value ($000) $2,374 Avg Close — Range —