TREVENA INC

CUSIP: 89532E109 Class: COM

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q1 2017
Shares 116,800 Value ($000) $429 Avg Close — Range —
Q2 2015
Shares 410,000 Value ($000) $2,567 Avg Close — Range —
Q1 2015
Shares 391,811 Value ($000) $2,555 Avg Close — Range —
Q4 2014
Shares 549,811 Value ($000) $3,288 Avg Close — Range —
Q3 2014
Shares 331,111 Value ($000) $2,126 Avg Close — Range —
Q2 2014
Shares 341,000 Value ($000) $1,927 Avg Close — Range —
Q1 2014
Shares 250,000 Value ($000) $1,965 Avg Close — Range —