TWILIO INC

Ticker: TWLO CUSIP: 90138F102 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q3 2021

Shares 35,500 Value ($000) $11,326 Avg Close $364.14 Range $311.18 - $412.68

Q2 2021

Shares 26,500 Value ($000) $10,445 Avg Close $347.16 Range $275.60 - $405.80

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2021	35,500	$11,326	$364.14	$311.18 - $412.68
Q2 2021	26,500	$10,445	$347.16	$275.60 - $405.80