TWIST BIOSCIENCE CORP

Ticker: TWST CUSIP: 90184D100 Class: Common Stock

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 25,865 Value ($000) $820 Avg Close $31.20 Range $23.30 - $35.39

Q3 2025

Shares 28,133 Value ($000) $792 Avg Close $30.29 Range $24.07 - $39.37

Q2 2025

Shares 29,694 Value ($000) $1,092 Avg Close $34.55 Range $27.12 - $42.07

Q1 2025

Shares 30,922 Value ($000) $1,214 Avg Close $45.04 Range $34.35 - $55.33

Q4 2024

Shares 29,944 Value ($000) $1,391 Avg Close $45.19 Range $36.76 - $53.91

Q3 2024

Shares 30,001 Value ($000) $1,355 Avg Close $47.58 Range $36.62 - $60.90

Q2 2024

Shares 31,064 Value ($000) $1,531 Avg Close $40.78 Range $27.41 - $55.26

Q1 2024

Shares 29,960 Value ($000) $1,028 Avg Close $36.10 Range $31.90 - $43.21

Q4 2023

Shares 27,924 Value ($000) $1,029 Avg Close $23.12 Range $14.42 - $39.74

Q3 2023

Shares 53,591 Value ($000) $1,086 Avg Close $21.97 Range $18.23 - $27.36

Q2 2023

Shares 48,064 Value ($000) $983 Avg Close $14.98 Range $11.46 - $21.13

Q1 2023

Shares 45,510 Value ($000) $686 Avg Close $22.09 Range $14.52 - $31.51

Q4 2022

Shares 45,423 Value ($000) $1,073 Avg Close $29.00 Range $21.78 - $40.50

Q3 2022

Shares 49,184 Value ($000) $1,748 Avg Close $42.47 Range $32.13 - $58.76

Q2 2022

Shares 49,502 Value ($000) $1,725 Avg Close $35.42 Range $25.07 - $57.31

Q1 2022

Shares 50,040 Value ($000) $2,495 Avg Close $55.42 Range $38.08 - $84.63

Q4 2021

Shares 23,861 Value ($000) $1,858 Avg Close $102.64 Range $73.18 - $139.99

Q3 2021

Shares 23,985 Value ($000) $2,566 Avg Close $114.50 Range $90.53 - $135.25

Q2 2021

Shares 26,330 Value ($000) $3,508 Avg Close $116.25 Range $84.23 - $150.25

Q1 2021

Shares 26,115 Value ($000) $3,235 Avg Close $151.85 Range $102.86 - $214.07

Q4 2020

Shares 19,611 Value ($000) $2,771 Avg Close $110.94 Range $74.25 - $170.86

Q3 2020

Shares 18,739 Value ($000) $1,424 Avg Close $62.26 Range $43.61 - $79.72

Q2 2020

Shares 17,977 Value ($000) $755 Avg Close $35.88 Range $25.72 - $45.64

Q1 2020

Shares 15,914 Value ($000) $487 Avg Close $26.88 Range $18.52 - $35.91

Q4 2019

Shares 13,400 Value ($000) $281 Avg Close $23.40 Range $20.45 - $28.23

Q3 2019

Shares 13,821 Value ($000) $328 Avg Close $29.07 Range $23.08 - $35.95

Q2 2019

Shares 13,498 Value ($000) $392 Avg Close $26.45 Range $20.30 - $34.33

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	25,865	$820	$31.20	$23.30 - $35.39
Q3 2025	28,133	$792	$30.29	$24.07 - $39.37
Q2 2025	29,694	$1,092	$34.55	$27.12 - $42.07
Q1 2025	30,922	$1,214	$45.04	$34.35 - $55.33
Q4 2024	29,944	$1,391	$45.19	$36.76 - $53.91
Q3 2024	30,001	$1,355	$47.58	$36.62 - $60.90
Q2 2024	31,064	$1,531	$40.78	$27.41 - $55.26
Q1 2024	29,960	$1,028	$36.10	$31.90 - $43.21
Q4 2023	27,924	$1,029	$23.12	$14.42 - $39.74
Q3 2023	53,591	$1,086	$21.97	$18.23 - $27.36
Q2 2023	48,064	$983	$14.98	$11.46 - $21.13
Q1 2023	45,510	$686	$22.09	$14.52 - $31.51
Q4 2022	45,423	$1,073	$29.00	$21.78 - $40.50
Q3 2022	49,184	$1,748	$42.47	$32.13 - $58.76
Q2 2022	49,502	$1,725	$35.42	$25.07 - $57.31
Q1 2022	50,040	$2,495	$55.42	$38.08 - $84.63
Q4 2021	23,861	$1,858	$102.64	$73.18 - $139.99
Q3 2021	23,985	$2,566	$114.50	$90.53 - $135.25
Q2 2021	26,330	$3,508	$116.25	$84.23 - $150.25
Q1 2021	26,115	$3,235	$151.85	$102.86 - $214.07
Q4 2020	19,611	$2,771	$110.94	$74.25 - $170.86
Q3 2020	18,739	$1,424	$62.26	$43.61 - $79.72
Q2 2020	17,977	$755	$35.88	$25.72 - $45.64
Q1 2020	15,914	$487	$26.88	$18.52 - $35.91
Q4 2019	13,400	$281	$23.40	$20.45 - $28.23
Q3 2019	13,821	$328	$29.07	$23.08 - $35.95
Q2 2019	13,498	$392	$26.45	$20.30 - $34.33