| ARK Investment Management LLC | 7,559,495 | $239,787 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 5,954,429 | $188,874 |
| BlackRock, Inc. | 5,894,972 | $186,989 |
| Artisan Partners Limited Partnership | 5,830,205 | $184,934 |
| VANGUARD GROUP INC | 5,776,198 | $183,221 |
| EdgePoint Investment Group Inc. | 5,377,991 | $170,590 |
| STATE STREET CORP | 3,627,818 | $115,074 |
| Sumitomo Mitsui Trust Holdings, Inc. | 1,902,829 | $60,358 |
| Nikko Asset Management Americas, Inc. | 1,902,829 | $60,263 |
| Soleus Capital Management, L.P. | 1,861,802 | $59,056 |
| GOLDMAN SACHS GROUP INC | 1,696,594 | $53,816 |
| MILLENNIUM MANAGEMENT LLC | 1,497,746 | $47,509 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,459,274 | $46,297 |
| Thrivent Financial for Lutherans | 1,361,355 | $43 |
| Invesco Ltd. | 1,290,271 | $40,927 |
| BAILLIE GIFFORD & CO | 1,276,195 | $40,481 |
| UBS ASSET MANAGEMENT AMERICAS INC | 1,173,100 | $37,211 |
| First Light Asset Management, LLC | 1,140,771 | $36,185 |
| MORGAN STANLEY | 866,356 | $27,481 |
| AMERICAN CENTURY COMPANIES INC | 865,634 | $27,458 |
| Tao Capital Management LP | 828,815 | $26,290 |
| DIMENSIONAL FUND ADVISORS LP | 815,369 | $25,865 |
| WELLINGTON MANAGEMENT GROUP LLP | 813,122 | $25,792 |
| UBS Group AG | 662,317 | $21,009 |
| JENNISON ASSOCIATES LLC | 618,933 | $19,633 |
| NEW YORK STATE COMMON RETIREMENT FUND | 591,180 | $18,752 |
| BALYASNY ASSET MANAGEMENT L.P. | 579,370 | $18,378 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 548,392 | $17,395 |
| STEMPOINT CAPITAL LP | 518,355 | $16,442 |
| NORTHERN TRUST CORP | 504,838 | $16,013 |
| Freshford Capital Management, LLC | 420,171 | $13,328 |
| BNP PARIBAS ARBITRAGE, SA | 415,609 | $13,183 |
| CITIGROUP INC | 401,282 | $12,729 |
| BANK OF AMERICA CORP /DE/ | 399,354 | $12,668 |
| Blue Water Life Science Advisors, LP | 383,000 | $12,149 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 371,552 | $11,786 |
| abrdn plc | 308,116 | $9,773 |
| Nuveen, LLC | 290,556 | $9,216 |
| PEREGRINE CAPITAL MANAGEMENT LLC | 288,283 | $9,144 |
| SEI INVESTMENTS CO | 270,099 | $8,568 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 269,093 | $8,536 |
| OSTERWEIS CAPITAL MANAGEMENT INC | 256,878 | $8,148 |
| JUPITER ASSET MANAGEMENT LTD | 243,669 | $7,729 |
| Pictet Asset Management Holding SA | 222,647 | $7,302 |
| JPMORGAN CHASE & CO | 215,147 | $6,824 |
| Ensign Peak Advisors, Inc | 212,593 | $6,743 |
| Trexquant Investment LP | 198,473 | $6,296 |
| BARCLAYS PLC | 194,071 | $6,156 |
| Bank of New York Mellon Corp | 182,941 | $5,803 |
| Qube Research & Technologies Ltd | 171,972 | $5,455 |
| Legal & General Group Plc | 171,206 | $5,431 |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 153,172 | $4,859 |
| Schonfeld Strategic Advisors LLC | 139,893 | $4,437 |
| ODDO BHF ASSET MANAGEMENT SAS | 135,650 | $4,303 |
| NEUBERGER BERMAN GROUP LLC | 135,622 | $4,302 |
| Vestmark Advisory Solutions, Inc. | 129,990 | $4,123 |
| AQR CAPITAL MANAGEMENT LLC | 129,552 | $4,109 |
| Swiss National Bank | 119,000 | $3,775 |
| Rafferty Asset Management, LLC | 114,258 | $3,624 |
| NATIXIS | 103,688 | $3,289 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 103,117 | $3,271 |
| FRED ALGER MANAGEMENT, LLC | 94,111 | $2,985 |
| RHUMBLINE ADVISERS | 91,122 | $2,890 |
| BLAIR WILLIAM & CO/IL | 81,561 | $2,587 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 80,552 | $2,555 |
| Aquatic Capital Management LLC | 78,469 | $2,489 |
| SG Americas Securities, LLC | 76,484 | $2 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 76,318 | $2,424 |
| WELLS FARGO & COMPANY/MN | 74,819 | $2,373 |
| HRT FINANCIAL LP | 73,127 | $2 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,753 | $2,244 |
| FMR LLC | 68,937 | $2,187 |
| ALLIANCEBERNSTEIN L.P. | 66,524 | $2,110 |
| LAZARD ASSET MANAGEMENT LLC | 66,027 | $2,094 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 65,122 | $2,083 |
| CANADA PENSION PLAN INVESTMENT BOARD | 60,200 | $1,910 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 58,985 | $2 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 58,337 | $1,850 |
| Conestoga Capital Advisors, LLC | 56,785 | $1,801 |
| DEUTSCHE BANK AG\ | 55,671 | $1,766 |
| FRANKLIN RESOURCES INC | 53,881 | $1,709 |
| LPL Financial LLC | 53,043 | $1,683 |
| IEQ CAPITAL, LLC | 51,335 | $1,628 |
| Clarius Group, LLC | 49,635 | $1,574 |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 44,668 | $1,447 |
| PROFUND ADVISORS LLC | 42,355 | $1,344 |
| ALGERT GLOBAL LLC | 40,601 | $1 |
| HighMark Wealth Management LLC | 39,462 | $1,252 |
| ENVESTNET ASSET MANAGEMENT INC | 38,649 | $1,226 |
| VICTORY CAPITAL MANAGEMENT INC | 37,555 | $1,191 |
| Squarepoint Ops LLC | 35,717 | $1,133 |
| Maxi Investments CY Ltd | 35,000 | $1 |
| STATE OF WISCONSIN INVESTMENT BOARD | 34,547 | $1,096 |
| AMERIPRISE FINANCIAL INC | 33,348 | $1,058 |
| MetLife Investment Management, LLC | 33,236 | $1,054 |
| ROYAL BANK OF CANADA | 33,234 | $1,054 |
| CITADEL ADVISORS LLC | 32,049 | $1,017 |
| TWO SIGMA ADVISERS, LP | 31,400 | $996 |
| BENJAMIN EDWARDS INC | 29,632 | $940 |
| D. E. Shaw & Co., Inc. | 27,581 | $875 |
| 141 other institutions | 917,845 | $26,807 |