TYRA BIOSCIENCES INC

Ticker: TYRA CUSIP: 90240B106 Class: Common Stock

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 8,357 Value ($000) $220 Avg Close $18.37 Range $12.98 - $26.41

Q4 2024

Shares 13,368 Value ($000) $186 Avg Close $18.15 Range $13.27 - $29.60

Q3 2024

Shares 14,184 Value ($000) $333 Avg Close $20.99 Range $15.53 - $25.14

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	8,357	$220	$18.37	$12.98 - $26.41
Q4 2024	13,368	$186	$18.15	$13.27 - $29.60
Q3 2024	14,184	$333	$20.99	$15.53 - $25.14