| RA CAPITAL MANAGEMENT, L.P. | 12,198,625 | $320,702 |
| Nextech Invest, Ltd. | 4,055,861 | $106,629 |
| Alta Partners Management Company, L.P. | 3,823,425 | $100,518 |
| Commodore Capital LP | 3,375,000 | $88,729 |
| Canaan Partners XI LLC | 3,374,329 | $88,711 |
| JANUS HENDERSON GROUP PLC | 2,935,442 | $77,085 |
| TCG Crossover Management, LLC | 2,898,103 | $76,191 |
| Vestal Point Capital, LP | 2,425,000 | $63,753 |
| BVF INC/IL | 2,127,665 | $55,936 |
| BlackRock, Inc. | 2,086,423 | $54,852 |
| FARALLON CAPITAL MANAGEMENT LLC | 2,066,818 | $54,337 |
| VANGUARD GROUP INC | 1,572,785 | $41,349 |
| Kynam Capital Management, LP | 1,564,492 | $41,130 |
| 5AM Venture Management, LLC | 1,029,298 | $27,060 |
| Caligan Partners LP | 944,257 | $24,825 |
| Point72 Asset Management, L.P. | 874,192 | $22,983 |
| BALYASNY ASSET MANAGEMENT L.P. | 818,326 | $21,514 |
| STATE STREET CORP | 749,463 | $19,703 |
| MARSHALL WACE, LLP | 711,891 | $18,716 |
| Trails Edge Capital Partners, LP | 700,000 | $18,403 |
| GEODE CAPITAL MANAGEMENT, LLC | 657,756 | $17,296 |
| Sio Capital Management, LLC | 526,002 | $13,829 |
| BOONE CAPITAL MANAGEMENT LLC | 398,482 | $10,476 |
| Elmind Capital, LP | 350,000 | $9,202 |
| Eversept Partners, LP | 278,564 | $7,323 |
| BOOTHBAY FUND MANAGEMENT, LLC | 221,177 | $5,815 |
| Logos Global Management LP | 210,000 | $5,521 |
| NORTHERN TRUST CORP | 200,956 | $5,283 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 199,426 | $5,243 |
| GOLDMAN SACHS GROUP INC | 182,387 | $4,795 |
| RAYMOND JAMES FINANCIAL INC | 170,032 | $4,470 |
| BNP Paribas Investment Partners S.A. | 129,779 | $3 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 129,753 | $3,411 |
| Invesco Ltd. | 129,435 | $3,403 |
| Soleus Capital Management, L.P. | 125,000 | $3,286 |
| BNP PARIBAS ARBITRAGE, SA | 120,278 | $3,162 |
| MORGAN STANLEY | 118,898 | $3,126 |
| MILLENNIUM MANAGEMENT LLC | 114,388 | $3,007 |
| TWO SIGMA INVESTMENTS, LP | 107,023 | $2,814 |
| WELLINGTON MANAGEMENT GROUP LLP | 104,305 | $2,742 |
| DIMENSIONAL FUND ADVISORS LP | 95,640 | $2,514 |
| INVESTMENT COUNSEL CO OF NEVADA | 85,020 | $2,235 |
| OPPENHEIMER & CO INC | 84,726 | $2,227 |
| Seven Fleet Capital Management LP | 79,560 | $2,092 |
| BARCLAYS PLC | 76,309 | $2,006 |
| Kalehua Capital Management LLC | 74,465 | $1,958 |
| JPMORGAN CHASE & CO | 71,175 | $1,871 |
| Bank of New York Mellon Corp | 60,901 | $1,601 |
| TWO SIGMA ADVISERS, LP | 58,900 | $1,548 |
| UBS Group AG | 58,856 | $1,547 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 58,677 | $1,543 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,135 | $1,449 |
| AMERIPRISE FINANCIAL INC | 54,625 | $1,436 |
| Squarepoint Ops LLC | 54,424 | $1,431 |
| Susquehanna Portfolio Strategies, LLC | 48,644 | $1,279 |
| Nuveen, LLC | 47,349 | $1,245 |
| ALGERT GLOBAL LLC | 46,870 | $1 |
| AMERICAN CENTURY COMPANIES INC | 46,227 | $1,215 |
| Y-Intercept (Hong Kong) Ltd | 45,942 | $1,208 |
| ALPS ADVISORS INC | 43,827 | $1,152 |
| ExodusPoint Capital Management, LP | 42,791 | $1,125 |
| PDT Partners, LLC | 42,284 | $1,112 |
| STATE OF WISCONSIN INVESTMENT BOARD | 39,023 | $1,026 |
| RHUMBLINE ADVISERS | 38,790 | $1,020 |
| BANK OF AMERICA CORP /DE/ | 38,310 | $1,007 |
| HighVista Strategies LLC | 35,086 | $922 |
| ALLIANCEBERNSTEIN L.P. | 31,990 | $841 |
| XTX Topco Ltd | 30,414 | $800 |
| Voya Investment Management LLC | 29,887 | $786 |
| WELLS FARGO & COMPANY/MN | 29,049 | $764 |
| CANADA PENSION PLAN INVESTMENT BOARD | 28,900 | $760 |
| Fisher Asset Management, LLC | 28,800 | $757 |
| AQR CAPITAL MANAGEMENT LLC | 28,631 | $753 |
| PSP Research LLC | 21,853 | $575 |
| Auour Investments LLC | 21,020 | $553 |
| Creative Planning | 19,603 | $515 |
| VICTORY CAPITAL MANAGEMENT INC | 18,790 | $494 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 18,542 | $487 |
| DEUTSCHE BANK AG\ | 16,377 | $431 |
| Rafferty Asset Management, LLC | 15,455 | $406 |
| MetLife Investment Management, LLC | 15,356 | $404 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14,432 | $0 |
| Russell Investments Group, Ltd. | 12,996 | $342 |
| FRANKLIN RESOURCES INC | 12,970 | $341 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12,908 | $339 |
| FMR LLC | 12,563 | $330 |
| Virtus Investment Advisers, LLC | 11,756 | $309 |
| BANK OF NOVA SCOTIA | 11,100 | $292 |
| BAKER BROS. ADVISORS LP | 10,607 | $279 |
| INTECH INVESTMENT MANAGEMENT LLC | 9,801 | $258 |
| VARCOV Co. | 9,708 | $255 |
| China Universal Asset Management Co., Ltd. | 8,697 | $229 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 8,357 | $220 |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,423 | $195 |
| Police & Firemen's Retirement System of New Jersey | 6,440 | $169 |
| CITIGROUP INC | 3,817 | $100 |
| Bellevue Group AG | 3,143 | $83 |
| Caitong International Asset Management Co., Ltd | 2,997 | $79 |
| Mirae Asset Global Investments Co., Ltd. | 2,594 | $68 |
| Legal & General Group Plc | 2,367 | $62 |
| 33 other institutions | 19,683 | $450 |