TYRA BIOSCIENCES INC

Ticker: TYRA CUSIP: 90240B106 Class: Common Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 58,900 Value ($000) $1,548 Avg Close $18.37 Range $12.98 - $26.41

Q3 2025

Shares 113,200 Value ($000) $1,584 Avg Close $11.40 Range $9.10 - $14.02

Q2 2025

Shares 87,000 Value ($000) $833 Avg Close $9.50 Range $6.42 - $12.00

Q1 2025

Shares 50,100 Value ($000) $466 Avg Close $12.94 Range $9.04 - $17.27

Q4 2024

Shares 12,300 Value ($000) $171 Avg Close $18.15 Range $13.27 - $29.60

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	58,900	$1,548	$18.37	$12.98 - $26.41
Q3 2025	113,200	$1,584	$11.40	$9.10 - $14.02
Q2 2025	87,000	$833	$9.50	$6.42 - $12.00
Q1 2025	50,100	$466	$12.94	$9.04 - $17.27
Q4 2024	12,300	$171	$18.15	$13.27 - $29.60