ULTRAGENYX PHARMACEUTICAL IN

Ticker: RARE CUSIP: 90400D108 Class: EQTY

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 424,049 Value ($000) $9,753 Avg Close $32.88 Range $18.41 - $39.89

Q3 2025

Shares 326,180 Value ($000) $9,811 Avg Close $29.99 Range $25.81 - $42.37

Q2 2025

Shares 576,901 Value ($000) $20,976 Avg Close $36.05 Range $29.59 - $40.19

Q1 2025

Shares 633,152 Value ($000) $22,926 Avg Close $41.60 Range $35.53 - $46.50

Q4 2024

Shares 614,948 Value ($000) $25,871 Avg Close $49.61 Range $41.26 - $57.99

Q3 2024

Shares 755,683 Value ($000) $41,978 Avg Close $50.94 Range $39.65 - $60.37

Q2 2024

Shares 568,309 Value ($000) $23,358 Avg Close $42.70 Range $37.02 - $52.56

Q1 2024

Shares 415,314 Value ($000) $19,391 Avg Close $47.17 Range $41.87 - $54.56

Q4 2023

Shares 126,610 Value ($000) $6,054 Avg Close $38.77 Range $31.52 - $49.93

Q3 2023

Shares 39,200 Value ($000) $1,397 Avg Close $39.62 Range $34.33 - $47.08

Q2 2023

Shares 403,774 Value ($000) $18,626 Avg Close $46.38 Range $37.20 - $54.98

Q1 2023

Shares 488,356 Value ($000) $19,583 Avg Close $42.91 Range $35.72 - $49.31

Q4 2022

Shares 441,936 Value ($000) $20,475 Avg Close $39.33 Range $33.36 - $46.51

Q3 2022

Shares 255,389 Value ($000) $10,576 Avg Close $51.39 Range $39.55 - $68.68

Q2 2022

Shares 56,500 Value ($000) $3,371 Avg Close $61.54 Range $45.20 - $85.53

Q1 2022

Shares 38,900 Value ($000) $2,825 Avg Close $69.58 Range $61.20 - $88.12

Q3 2021

Shares 25,900 Value ($000) $2,336 Avg Close $90.39 Range $76.78 - $104.38

Q2 2021

Shares 290,264 Value ($000) $27,677 Avg Close $104.18 Range $91.93 - $120.00

Q1 2021

Shares 144,320 Value ($000) $16,432 Avg Close $136.14 Range $102.90 - $175.00

Q4 2020

Shares 60,312 Value ($000) $8,349 Avg Close $118.63 Range $82.43 - $179.65

Q3 2020

Shares 5,717 Value ($000) $470 Avg Close $82.89 Range $72.83 - $91.77

Q2 2020

Shares 39,554 Value ($000) $3,094 Avg Close $66.19 Range $42.32 - $79.67

Q3 2019

Shares 7,759 Value ($000) $332 Avg Close $54.32 Range $41.35 - $65.00

Q3 2015

Shares 150,113 Value ($000) $14,457 Avg Close $114.50 Range $83.40 - $137.05

Q2 2015

Shares 145,341 Value ($000) $14,881 Avg Close $77.65 Range $56.11 - $105.97

Q1 2015

Shares 12,821 Value ($000) $796 Avg Close $55.55 Range $44.27 - $65.35

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	424,049	$9,753	$32.88	$18.41 - $39.89
Q3 2025	326,180	$9,811	$29.99	$25.81 - $42.37
Q2 2025	576,901	$20,976	$36.05	$29.59 - $40.19
Q1 2025	633,152	$22,926	$41.60	$35.53 - $46.50
Q4 2024	614,948	$25,871	$49.61	$41.26 - $57.99
Q3 2024	755,683	$41,978	$50.94	$39.65 - $60.37
Q2 2024	568,309	$23,358	$42.70	$37.02 - $52.56
Q1 2024	415,314	$19,391	$47.17	$41.87 - $54.56
Q4 2023	126,610	$6,054	$38.77	$31.52 - $49.93
Q3 2023	39,200	$1,397	$39.62	$34.33 - $47.08
Q2 2023	403,774	$18,626	$46.38	$37.20 - $54.98
Q1 2023	488,356	$19,583	$42.91	$35.72 - $49.31
Q4 2022	441,936	$20,475	$39.33	$33.36 - $46.51
Q3 2022	255,389	$10,576	$51.39	$39.55 - $68.68
Q2 2022	56,500	$3,371	$61.54	$45.20 - $85.53
Q1 2022	38,900	$2,825	$69.58	$61.20 - $88.12
Q3 2021	25,900	$2,336	$90.39	$76.78 - $104.38
Q2 2021	290,264	$27,677	$104.18	$91.93 - $120.00
Q1 2021	144,320	$16,432	$136.14	$102.90 - $175.00
Q4 2020	60,312	$8,349	$118.63	$82.43 - $179.65
Q3 2020	5,717	$470	$82.89	$72.83 - $91.77
Q2 2020	39,554	$3,094	$66.19	$42.32 - $79.67
Q3 2019	7,759	$332	$54.32	$41.35 - $65.00
Q3 2015	150,113	$14,457	$114.50	$83.40 - $137.05
Q2 2015	145,341	$14,881	$77.65	$56.11 - $105.97
Q1 2015	12,821	$796	$55.55	$44.27 - $65.35