| VANGUARD GROUP INC | 10,263,815 | $236,068 |
| BlackRock, Inc. | 6,631,554 | $152,526 |
| STATE STREET CORP | 4,303,046 | $98,970 |
| JPMORGAN CHASE & CO | 3,974,030 | $91,403 |
| SANDS CAPITAL MANAGEMENT, LLC | 3,485,724 | $80,172 |
| RTW INVESTMENTS, LP | 3,000,139 | $69,003 |
| BAKER BROS. ADVISORS LP | 2,772,692 | $63,772 |
| FMR LLC | 2,666,249 | $61,324 |
| WELLINGTON MANAGEMENT GROUP LLP | 2,461,910 | $56,624 |
| CITADEL ADVISORS LLC | 2,326,125 | $53,501 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,019,000 | $46,437 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,965,084 | $45,197 |
| BNP Paribas Investment Partners S.A. | 1,899,661 | $44 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,838,208 | $42,287 |
| MORGAN STANLEY | 1,826,295 | $42,005 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,749,268 | $40,233 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,554,366 | $36 |
| abrdn plc | 1,469,951 | $33,809 |
| GW&K Investment Management, LLC | 1,375,407 | $32 |
| AQR CAPITAL MANAGEMENT LLC | 1,360,497 | $31,291 |
| Rock Springs Capital Management LP | 1,267,241 | $29,147 |
| NORGES BANK | 1,261,026 | $29,004 |
| Pictet Asset Management Holding SA | 1,231,331 | $26,563 |
| BANK OF AMERICA CORP /DE/ | 1,213,928 | $27,920 |
| JANE STREET GROUP, LLC | 1,021,499 | $23,494 |
| BNP PARIBAS ARBITRAGE, SA | 903,050 | $20,770 |
| MILLENNIUM MANAGEMENT LLC | 880,644 | $20,255 |
| Russell Investments Group, Ltd. | 840,820 | $19,339 |
| Nuveen, LLC | 801,473 | $18,434 |
| Candriam S.C.A. | 799,384 | $18,387 |
| Schonfeld Strategic Advisors LLC | 741,618 | $17,057 |
| UBS Group AG | 668,811 | $15,383 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 643,356 | $14,797 |
| DEUTSCHE BANK AG\ | 599,473 | $13,788 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 598,924 | $13,775 |
| Polar Capital Holdings Plc | 556,628 | $12,802 |
| NORTHERN TRUST CORP | 526,686 | $12,114 |
| BALYASNY ASSET MANAGEMENT L.P. | 520,054 | $11,961 |
| HRT FINANCIAL LP | 501,679 | $12 |
| TWO SIGMA ADVISERS, LP | 481,600 | $11,077 |
| Jefferies Financial Group Inc. | 477,092 | $10,973 |
| Palo Alto Investors LP | 461,294 | $10,610 |
| TWO SIGMA INVESTMENTS, LP | 424,049 | $9,753 |
| FRED ALGER MANAGEMENT, LLC | 411,863 | $9,473 |
| Legal & General Group Plc | 411,273 | $9,459 |
| GOLDMAN SACHS GROUP INC | 400,358 | $9,208 |
| Squarepoint Ops LLC | 390,599 | $8,984 |
| RENAISSANCE TECHNOLOGIES LLC | 366,100 | $8,420 |
| BARCLAYS PLC | 359,148 | $8,260 |
| Privium Fund Management B.V. | 357,502 | $8,223 |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 348,350 | $8,012 |
| D. E. Shaw & Co., Inc. | 344,763 | $7,930 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 331,169 | $7,605 |
| GordonMD Global Investments LP | 329,101 | $7,569 |
| Eversept Partners, LP | 317,182 | $7,295 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 310,108 | $7,132 |
| FRANKLIN RESOURCES INC | 309,062 | $7,108 |
| SPHERA FUNDS MANAGEMENT LTD. | 300,623 | $6,914 |
| GREAT POINT PARTNERS LLC | 300,000 | $6,900 |
| Bank of New York Mellon Corp | 298,706 | $6,870 |
| Motley Fool Wealth Management, LLC | 297,486 | $6,842 |
| Newtyn Management, LLC | 295,915 | $6,806 |
| Verition Fund Management LLC | 282,376 | $6,495 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 280,000 | $6,440 |
| AMERIPRISE FINANCIAL INC | 276,927 | $6,369 |
| Connor, Clark & Lunn Investment Management Ltd. | 263,869 | $6,069 |
| Ensign Peak Advisors, Inc | 250,571 | $5,763 |
| Invesco Ltd. | 230,271 | $5,296 |
| 683 Capital Management, LLC | 222,395 | $5,115 |
| Caption Management, LLC | 219,500 | $5,049 |
| ALGERT GLOBAL LLC | 219,232 | $5 |
| Blue Owl Capital Holdings LP | 212,638 | $4,891 |
| EMERALD ADVISERS, LLC | 212,358 | $4,884 |
| UBS ASSET MANAGEMENT AMERICAS INC | 204,107 | $4,694 |
| MOORE CAPITAL MANAGEMENT, LP | 200,000 | $4,600 |
| Assenagon Asset Management S.A. | 199,720 | $4,594 |
| Fisher Asset Management, LLC | 198,696 | $4,570 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 182,808 | $4,205 |
| PDT Partners, LLC | 176,813 | $4,067 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 175,635 | $4,001 |
| Woodline Partners LP | 171,805 | $3,952 |
| Swiss National Bank | 171,052 | $3,934 |
| Trexquant Investment LP | 165,017 | $3,795 |
| WCM INVESTMENT MANAGEMENT, LLC | 163,272 | $3,719 |
| ROYAL BANK OF CANADA | 163,227 | $3,754 |
| Catalio Capital Management, LP | 162,550 | $3,739 |
| Rafferty Asset Management, LLC | 157,061 | $3,612 |
| SEI INVESTMENTS CO | 153,726 | $3,536 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 152,316 | $3,503 |
| CAPITAL FUND MANAGEMENT S.A. | 150,201 | $3,455 |
| Krensavage Asset Management, LLC | 149,634 | $3 |
| SR ONE CAPITAL MANAGEMENT, LP | 137,753 | $3,168 |
| ExodusPoint Capital Management, LP | 137,392 | $3,160 |
| B Group, Inc. | 135,000 | $3,105 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 134,467 | $4,729 |
| Caitong International Asset Management Co., Ltd | 122,854 | $2,826 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 120,505 | $2,772 |
| XTX Topco Ltd | 119,996 | $2,760 |
| COMERICA BANK | 118,422 | $2,724 |
| Jump Financial, LLC | 115,928 | $2,666 |
| 184 other institutions | 4,160,754 | $89,978 |