ULTRAGENYX PHARMACEUTICAL IN

Ticker: RARE CUSIP: 90400D108 Class: EQTY

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 481,600 Value ($000) $11,077 Avg Close $32.88 Range $18.41 - $39.89

Q3 2025

Shares 517,700 Value ($000) $15,572 Avg Close $29.99 Range $25.81 - $42.37

Q2 2025

Shares 860,400 Value ($000) $31,284 Avg Close $36.05 Range $29.59 - $40.19

Q1 2025

Shares 937,200 Value ($000) $33,936 Avg Close $41.60 Range $35.53 - $46.50

Q4 2024

Shares 913,500 Value ($000) $38,431 Avg Close $49.61 Range $41.26 - $57.99

Q3 2024

Shares 987,800 Value ($000) $54,872 Avg Close $50.94 Range $39.65 - $60.37

Q2 2024

Shares 442,200 Value ($000) $18,174 Avg Close $42.70 Range $37.02 - $52.56

Q1 2024

Shares 448,200 Value ($000) $20,926 Avg Close $47.17 Range $41.87 - $54.56

Q4 2023

Shares 188,900 Value ($000) $9,033 Avg Close $38.77 Range $31.52 - $49.93

Q3 2023

Shares 229,500 Value ($000) $8,182 Avg Close $39.62 Range $34.33 - $47.08

Q2 2023

Shares 490,500 Value ($000) $22,627 Avg Close $46.38 Range $37.20 - $54.98

Q1 2023

Shares 497,900 Value ($000) $19,966 Avg Close $42.91 Range $35.72 - $49.31

Q4 2022

Shares 460,700 Value ($000) $21,344 Avg Close $39.33 Range $33.36 - $46.51

Q3 2022

Shares 51,400 Value ($000) $2,128 Avg Close $51.39 Range $39.55 - $68.68

Q3 2021

Shares 69,400 Value ($000) $6,259 Avg Close $90.39 Range $76.78 - $104.38

Q2 2021

Shares 137,900 Value ($000) $13,149 Avg Close $104.18 Range $91.93 - $120.00

Q1 2021

Shares 132,100 Value ($000) $15,041 Avg Close $136.14 Range $102.90 - $175.00

Q4 2020

Shares 59,700 Value ($000) $8,264 Avg Close $118.63 Range $82.43 - $179.65

Q3 2020

Shares 37,400 Value ($000) $3,074 Avg Close $82.89 Range $72.83 - $91.77

Q2 2020

Shares 39,300 Value ($000) $3,074 Avg Close $66.19 Range $42.32 - $79.67

Q4 2015

Shares 91,586 Value ($000) $10,274 Avg Close $99.99 Range $79.34 - $117.12

Q3 2015

Shares 158,400 Value ($000) $15,398 Avg Close $114.50 Range $83.40 - $137.05

Q2 2015

Shares 54,400 Value ($000) $5,570 Avg Close $77.65 Range $56.11 - $105.97

Q1 2015

Shares 4,100 Value ($000) $255 Avg Close $55.55 Range $44.27 - $65.35

Q3 2014

Shares 9,800 Value ($000) $555 Avg Close $50.32 Range $37.77 - $60.04

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	481,600	$11,077	$32.88	$18.41 - $39.89
Q3 2025	517,700	$15,572	$29.99	$25.81 - $42.37
Q2 2025	860,400	$31,284	$36.05	$29.59 - $40.19
Q1 2025	937,200	$33,936	$41.60	$35.53 - $46.50
Q4 2024	913,500	$38,431	$49.61	$41.26 - $57.99
Q3 2024	987,800	$54,872	$50.94	$39.65 - $60.37
Q2 2024	442,200	$18,174	$42.70	$37.02 - $52.56
Q1 2024	448,200	$20,926	$47.17	$41.87 - $54.56
Q4 2023	188,900	$9,033	$38.77	$31.52 - $49.93
Q3 2023	229,500	$8,182	$39.62	$34.33 - $47.08
Q2 2023	490,500	$22,627	$46.38	$37.20 - $54.98
Q1 2023	497,900	$19,966	$42.91	$35.72 - $49.31
Q4 2022	460,700	$21,344	$39.33	$33.36 - $46.51
Q3 2022	51,400	$2,128	$51.39	$39.55 - $68.68
Q3 2021	69,400	$6,259	$90.39	$76.78 - $104.38
Q2 2021	137,900	$13,149	$104.18	$91.93 - $120.00
Q1 2021	132,100	$15,041	$136.14	$102.90 - $175.00
Q4 2020	59,700	$8,264	$118.63	$82.43 - $179.65
Q3 2020	37,400	$3,074	$82.89	$72.83 - $91.77
Q2 2020	39,300	$3,074	$66.19	$42.32 - $79.67
Q4 2015	91,586	$10,274	$99.99	$79.34 - $117.12
Q3 2015	158,400	$15,398	$114.50	$83.40 - $137.05
Q2 2015	54,400	$5,570	$77.65	$56.11 - $105.97
Q1 2015	4,100	$255	$55.55	$44.27 - $65.35
Q3 2014	9,800	$555	$50.32	$37.77 - $60.04