UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

STATE STREET CORP's Holding History (CIK: 0000093751)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,319,226 Value ($000) $35,817 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 1,114,581 Value ($000) $20,965 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 481,375 Value ($000) $5,285 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 295,587 Value ($000) $1,809 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 247,187 Value ($000) $4,064 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,319,226	$35,817	$24.89	$18.05 - $33.00
Q3 2025	1,114,581	$20,965	$15.54	$10.54 - $21.03
Q2 2025	481,375	$5,285	$9.24	$5.14 - $12.10
Q1 2025	295,587	$1,809	$9.55	$6.12 - $18.95
Q4 2024	247,187	$4,064	$22.33	$14.97 - $29.46