| FMR LLC | 7,518,202 | $204,119 |
| ORBIMED ADVISORS LLC | 5,693,589 | $154,581 |
| BlackRock, Inc. | 3,344,504 | $90,803 |
| Decheng Capital LLC | 3,143,078 | $85,335 |
| NORGES BANK | 2,882,647 | $78,264 |
| Enavate Sciences GP, LLC | 2,459,703 | $66,781 |
| VANGUARD GROUP INC | 2,388,439 | $64,846 |
| UBS Group AG | 1,806,243 | $49,039 |
| JANUS HENDERSON GROUP PLC | 1,527,958 | $41,423 |
| Altshuler Shaham Ltd | 1,341,540 | $36,423 |
| Bain Capital Life Sciences Investors, LLC | 1,329,544 | $36,097 |
| Omega Fund Management, LLC | 1,326,293 | $36,009 |
| STATE STREET CORP | 1,319,226 | $35,817 |
| VR Adviser, LLC | 1,169,298 | $31,746 |
| WELLINGTON MANAGEMENT GROUP LLP | 894,733 | $24,292 |
| GEODE CAPITAL MANAGEMENT, LLC | 851,908 | $23,134 |
| Parkman Healthcare Partners LLC | 834,559 | $22,658 |
| Pictet Asset Management Holding SA | 773,148 | $20,991 |
| Woodline Partners LP | 760,252 | $20,641 |
| Integral Health Asset Management, LLC | 750,000 | $20,363 |
| TCG Crossover Management, LLC | 743,886 | $20,197 |
| Samsara BioCapital, LLC | 736,047 | $19,984 |
| Vestal Point Capital, LP | 720,000 | $19,548 |
| Siren, L.L.C. | 588,450 | $15,976 |
| BARCLAYS PLC | 524,499 | $14,240 |
| MILLENNIUM MANAGEMENT LLC | 517,264 | $14,044 |
| Nantahala Capital Management, LLC | 494,971 | $13,438 |
| MARSHALL WACE, LLP | 343,791 | $9,334 |
| GOLDMAN SACHS GROUP INC | 333,481 | $9,054 |
| GREAT POINT PARTNERS LLC | 300,000 | $8,145 |
| Alyeska Investment Group, L.P. | 298,329 | $8,100 |
| JENNISON ASSOCIATES LLC | 288,847 | $7,842 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 284,931 | $7,736 |
| NORTHERN TRUST CORP | 236,799 | $6,429 |
| Squadron Capital Management LLC | 230,650 | $6,262 |
| Invesco Ltd. | 163,186 | $4,431 |
| Boxer Capital Management, LLC | 150,000 | $4,073 |
| DEUTSCHE BANK AG\ | 127,815 | $3,470 |
| MORGAN STANLEY | 122,068 | $3,314 |
| SummitTX Capital, L.P. | 116,724 | $3,169 |
| Schonfeld Strategic Advisors LLC | 115,807 | $3,144 |
| JPMORGAN CHASE & CO | 110,280 | $2,994 |
| AMERICAN CENTURY COMPANIES INC | 87,756 | $2,383 |
| BANK OF AMERICA CORP /DE/ | 86,384 | $2,345 |
| Bank of New York Mellon Corp | 84,853 | $2,304 |
| Nuveen, LLC | 78,568 | $2,133 |
| ExodusPoint Capital Management, LP | 75,402 | $2,047 |
| Artia Global Partners LP | 68,653 | $1,864 |
| Exome Asset Management LLC | 64,845 | $1,761 |
| AMERIPRISE FINANCIAL INC | 56,557 | $1,536 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,841 | $1,516 |
| SEVEN GRAND MANAGERS, LLC | 50,000 | $1,358 |
| Y-Intercept (Hong Kong) Ltd | 46,559 | $1,264 |
| ALPS ADVISORS INC | 44,376 | $1,205 |
| RHUMBLINE ADVISERS | 41,523 | $1,127 |
| Rafferty Asset Management, LLC | 38,683 | $1,050 |
| WELLS FARGO & COMPANY/MN | 36,794 | $999 |
| Trexquant Investment LP | 31,049 | $843 |
| ALLIANCEBERNSTEIN L.P. | 31,010 | $842 |
| AQR CAPITAL MANAGEMENT LLC | 30,503 | $828 |
| D. E. Shaw & Co., Inc. | 27,091 | $736 |
| Swiss National Bank | 26,600 | $722 |
| DIADEMA PARTNERS LP | 20,500 | $557 |
| MetLife Investment Management, LLC | 19,678 | $534 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 19,636 | $1 |
| PSP Research LLC | 17,634 | $479 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,491 | $475 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 16,560 | $450 |
| RENAISSANCE TECHNOLOGIES LLC | 16,400 | $445 |
| Quantinno Capital Management LP | 15,415 | $419 |
| XTX Topco Ltd | 15,091 | $410 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,652 | $398 |
| PROFUND ADVISORS LLC | 14,582 | $396 |
| Graham Capital Management, L.P. | 13,712 | $372 |
| Legal & General Group Plc | 13,709 | $372 |
| CITADEL ADVISORS LLC | 13,420 | $364 |
| DnB Asset Management AS | 12,793 | $347 |
| Virtu Financial LLC | 12,246 | $0 |
| Verition Fund Management LLC | 12,020 | $326 |
| Mariner, LLC | 11,830 | $321 |
| Creative Planning | 11,749 | $319 |
| NEW YORK STATE COMMON RETIREMENT FUND | 11,700 | $318 |
| TWO SIGMA INVESTMENTS, LP | 10,500 | $285 |
| INTECH INVESTMENT MANAGEMENT LLC | 10,396 | $282 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,147 | $275 |
| Virtus Investment Advisers, LLC | 9,801 | $266 |
| STRS OHIO | 9,800 | $266 |
| VARCOV Co. | 9,619 | $261 |
| Police & Firemen's Retirement System of New Jersey | 9,456 | $257 |
| Persistent Asset Partners Ltd | 8,907 | $242 |
| China Universal Asset Management Co., Ltd. | 8,806 | $239 |
| ProShare Advisors LLC | 8,354 | $227 |
| SEI INVESTMENTS CO | 8,087 | $220 |
| CITIGROUP INC | 6,949 | $189 |
| SG Americas Securities, LLC | 5,518 | $0 |
| BNP PARIBAS ARBITRAGE, SA | 4,976 | $135 |
| CWM, LLC | 3,360 | $0 |
| KLP KAPITALFORVALTNING AS | 2,900 | $79 |
| Russell Investments Group, Ltd. | 2,823 | $77 |
| Ameritas Investment Partners, Inc. | 2,741 | $74 |
| 31 other institutions | 14,527 | $361 |