UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

BARCLAYS PLC's Holding History (CIK: 0000312069)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 524,499 Value ($000) $14,240 Avg Close $24.89 Range $18.05 - $33.00

Q2 2025

Shares 96,990 Value ($000) $1,065 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 24,993 Value ($000) $153 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 27,017 Value ($000) $444 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	524,499	$14,240	$24.89	$18.05 - $33.00
Q2 2025	96,990	$1,065	$9.24	$5.14 - $12.10
Q1 2025	24,993	$153	$9.55	$6.12 - $18.95
Q4 2024	27,017	$444	$22.33	$14.97 - $29.46