UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

FMR LLC's Holding History (CIK: 0000315066)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 7,518,202 Value ($000) $204,119 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 8,086,413 Value ($000) $152,105 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 7,936,880 Value ($000) $87,147 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 7,255,859 Value ($000) $44,406 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 7,176,187 Value ($000) $117,977 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	7,518,202	$204,119	$24.89	$18.05 - $33.00
Q3 2025	8,086,413	$152,105	$15.54	$10.54 - $21.03
Q2 2025	7,936,880	$87,147	$9.24	$5.14 - $12.10
Q1 2025	7,255,859	$44,406	$9.55	$6.12 - $18.95
Q4 2024	7,176,187	$117,977	$22.33	$14.97 - $29.46