UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Clearstead Advisors, LLC's Holding History (CIK: 0000842775)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 163 Value ($000) $3 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 163 Value ($000) $2 Avg Close $9.24 Range $5.14 - $12.10

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	163	$3	$15.54	$10.54 - $21.03
Q2 2025	163	$2	$9.24	$5.14 - $12.10